Search results for senescence

“Mechanisms of senescence Senescent cells produce many chemical messengers to communicate their damaged state to neighboring cells. Researchers characterize senescent cells by the types of molecules they produce (e.g., proinflammatory cytokines, growth factors, enzymes, and lipids ), called a senescence-associated secretory phenotype (SASP).”

“What's interesting is that, while accumulating senescent cells is inevitable, there are varying strategies for tackling senescence, and this is of great interest to the field of aging. There are ways to clear out senescent cells with drugs or even dietary and lifestyle interventions.”

“More than a century of research has demonstrated that nicotinamide adenine dinucleotide (NAD+) is an indispensable mediator of vital metabolic and physiological processes, including energy production, DNA synthesis and repair, and regulation of gene expression – across multiple species.”

“In fact, telomerase levels in cancer cells are often as much as 10-fold higher than in normal, healthy replicating cells. In this clip, Dr. Elissa Epel discusses how having an optimal ratio of telomerase – high enough to reduce the risk of chronic disease, but low enough to reduce the risk of cancer – is key.”

“Cellular senescence is the condition or process of deterioration that occurs with age. Senescent cells produce a variety of factors believed to contribute to the aging process. Some scientists have posited that removal of senescent cells would naturally slow aging.”

“Cancer cells exploit the regenerative capacity of telomerase to perpetually divide, essentially becoming immortal. In this clip, Dr. Elissa Epel discusses how having an optimal ratio of telomerase – high enough to reduce the risk of chronic disease, but low enough to reduce the risk of cancer – is key.”

“Telomeres have been likened to aglets – the little plastic caps on the ends of shoestrings that prevent the string from fraying – and it's a good analogy. Telomeres are distinctive structures comprised of short, repetitive sequences of DNA present on the ends of chromosomes.”

“Studies in humans are needed to determine whether quercetin blunts any beneficial exercise adaptations. Quercetin and aging Relevance of senolytic compounds in aging Senescence is a condition or process of cellular deterioration that occurs with age.”

“Fasting or beta-hydroxybutyrate administration reduces the production of senescent cells. "Fasting or beta-hydroxybutyrate administration may activate youth-associated DNA factors that reduce senescence in mice and cell culture.".”

“Mitochondrial dysfunction, impaired mitochondrial function that occurs over time as mitochondrial membranes and energy production become less efficient. Cellular senescence, the process by which damaged cells terminate normal growth and reproduction cycles to prevent injured cells from proliferating.”