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“Circadian rhythms are the body’s 24-hour cycles of biological, hormonal, and behavioral patterns. Every organ and cell has its own daily timed circadian rhythm, which influences physiological processes, including the body’s production of hormones that regulate sleep, hunger, and metabolism.”

“When mice consume a diet that is high in fat and sugar, they tend to develop metabolic diseases, such as obesity, diabetes, and cardiovascular disease, much like humans who eat a similar diet.”

“People with Parkinson's disease can benefit from engaging in an intense exercise program that incorporates both a skilled and an aerobic component. Activities that involve gait and balance training are particularly useful.”

“In a ten-week randomized trial of 16 men with overweight or obesity, high-intensity training produced greater improvements than continuous aerobic training in peak VO2, glucose-tolerance-derived insulin-sensitivity measures, and muscle mitochondrial content.”

“In this Aliquot, Dr. Brad Schoenfeld describes a balanced approach to maximizing muscle growth and strength and dispels early myths about possible blunting effects of aerobic training, the need to train to failure, and the "go heavy or go home" philosophy.”

“To look for functional mitochondrial effects, Dr. Attia uses controlled Zone 2 work while sampling lactate, with output near 2 mmol/L. He says statins have not produced the clear lactate-performance changes he sees with metformin.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Dr. Rhonda Patrick discusses her supplement stack, avoiding microplastics, creatine for brain health, and mRNA vaccine autoimmunity risks.

“COVID-19 vaccines contain different spike proteins than the SARS-CoV-2 virus. All vaccines used in the United States contain two extra amino acids that lock the spike protein into the prefusion conformation, such that it cannot fuse with the cell membrane.”

“Dr. Schoenfeld asserts that resistance training alone is a poor strategy for losing weight and is most valuable when used as an adjunct to calorie reduction. If a person reduces their caloric intake to lose weight, as much as 30 percent of their weight loss may come from muscle – unless they engage in resistance training.”