Search results for aging

“Future work will need to test whether earlier or longer-term exercise, possibly in combination with other lifestyle strategies, can influence more stable layers of the aging epigenome and translate into meaningful gains in muscle function or resilience. In episode #62, Dr. Steve Horvath discusses epigenetic aging clocks and their use in predicting biological aging and healthspan.”

“Researchers in the field of aging have posited several theories to explain how and why the body ages. One of these theories, the somatic mutation theory of aging, is based on the idea that DNA damage accumulates over time – the result of day-to-day living and oxidative stress.”

“Research indicates that obesity roughly doubles a person's risk of premature death. Aging, the progressive accumulation of damage that occurs to an organism over time, eventually leads to disease and death.”

“DNA damage at telomeres drives senescence in cardiac cells. Removing senescent cardiac muscle cells from the hearts of aged mice, both genetically and using drugs, reduces hypertrophy and fibrosis in aged hearts and restores cardiac health.”

“Researchers investigated the health effects of AGEs in Caenorhabditis elegans, a type of roundworm often used to model human aging. Specifically, they looked at the effects of dietary AGEs derived from methylglyoxal, a byproduct of glycolysis and lipid peroxidation.”

“For optimal health, adults of all ages should engage in at least 150 minutes of moderate intensity physical exercise or at least 75 minutes of vigorous intensity physical exercise each week, or an equivalent combination of both.”

“Sleep is crucial for maintaining cognitive health throughout the lifespan. However, sleep quality often declines with age. Findings from a new study in mice suggest that overactive hypocretin neurons contribute to the poor sleep quality that often accompanies aging.”

“Lifestyle interventions that improve the aging process by reducing the number of medical conditions and medications used may improve microbiota quality. Link to full publication. Learn more about how the gut microbiota affects health in this episode featuring Drs.”

“They found that participants with vitamin D deficiency (which the researchers defined as less than 16.08 nanograms (ng) per milliliter (ml) for the purposes of this study) were more likely to have accelerated brain aging, as evidenced by lower total brain and gray matter volumes.”

“Multivitamins are among the most widely used dietary supplements, yet evidence that they influence biological aging remains limited. To see whether a simple daily multivitamin could affect that process, researchers tracked changes in epigenetic clocks, which are blood-based tools that estimate biological aging using chemical marks on DNA that influence how genes are used.”