Search results for bdnf

“Findings from a 2010 study demonstrate that modulating pathways involved in BDNF-mediated signaling shows promise as a therapeutic against Huntington's disease. Evidence suggests that normal huntingtin promotes the expression of BDNF, but mutated huntingtin impairs it.”

“A common variation in the BDNF gene called a single nucleotide polymorphism, or SNP, can alter how the BDNF protein functions. The SNP, known as Val66Met, results in the amino acid valine being replaced with methionine in the BDNF protein.”

“The authors of the current study used a water-based gel to deliver a solution of polysaccharide-BDNF particles to spinal cord-injured female rats. This delivery mode keeps the BDNF at the site of injury instead of allowing it to become more widely distributed.”

“Low BDNF concentrations are typical in psychiatric disorders but typically rise after antidepressant treatment and high omega-3 fatty acid doses. Exercise and DHA-rich diets also elevate BDNF, and some evidence suggests that BDNF mediates DHA's beneficial brain effects.”

“The authors of the study assessed the women's mental health history and current status and took blood samples to determine BDNF levels. Thirty (88 percent) of the women who had attempted suicide had a lifetime history of major depressive disorder.”

“Nearly 65 percent of the participants were at high risk for developing Alzheimer's disease, having at least one parent diagnosed with the condition. Each of the participants underwent cognitive assessment and BDNF genotyping five times over a period of four to 11 years.”

“In general, Black women had higher BDNF levels and lower cortisol levels than white women during pregnancy and postpartum. Lower levels of BDNF during the second and third trimesters were associated with higher risk for depression and lower birthweight babies, regardless of race.”

“Findings from a 2009 study suggest that variations in certain genes can impact the likelihood of relapsing following treatment. BDNF is involved in neuronal growth and survival, as well as influencing neurotransmitters – chemical signals from the nervous system.”

“Mitigation of oxidative stress as a mechanism of increased BDNF: > It has been shown that TBI can result in cumulative ROS, which may be associated with reduction of BDNF. Thus, DHA may help to counteract elevated levels of ROS with subsequent effects on the action of BDNF on synaptic plasticity and cognition after TBI.”

“The mechanisms associated with vigorous exercise—such as lactate signaling, BDNF, blood flow, and myokine release—are biologically interesting, but evidence from full workouts should not automatically be attributed to a 20-second snack.”