Search results for hypoxia

“It is commonly used to treat wounds and other medical conditions in which hypoxia is an underlying factor. The mechanisms by which hyperbaric oxygen therapy works involve epigenetic modulation of gene expression to mediate factors that drive disease and inflammation.”

“The cells exhibited changes in gene expression related to metabolic processes, heart development, and responses to hypoxia. They also produced more inflammation-associated metabolites.”

“However, some evidence suggests that ketone supplementation enhances performance in extreme settings in which hypoxia may be a factor, such as mountain climbing. Learn more in this clip featuring ketone expert Dr. Dominic D'Agostino. Read full publication.”

“Other preclinical research indicates that skilled exercise switches on the activity of hypoxia-inducible factor 1-alpha, commonly known as HIF-1α — a master transcription factor that influences how more than 40 genes are transcribed.”

“The researchers found that intestinal epithelial cells isolated from mice consuming fructose were better able to withstand low-oxygen conditions (called hypoxia), which is a common cause of intestinal cell death.”

“Disturbances in this system due to the loss of ACE2 function in the setting of SARS-CoV-2 infection can promote neutrophil infiltration, excessive inflammation, and lung injury. Once lung infection progresses to hypoxia, renin is released, setting up a vicious cycle for decreasing ACE2.”

“Over years, the repeated pattern of "intermittent hypoxia"—oxygen drops followed by reoxygenation—creates oxidative stress that may accelerate neurodegeneration. Severe, untreated OSA is now recognized as a risk factor for conditions like Alzheimer's disease.”

“Animal studies and theoretical rationales suggest potential benefits, especially under conditions of fetal stress (e.g., hypoxia, placental insufficiency). However, until robust human trials confirm safety and efficacy, official recommendations remain cautious.”

“Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects.”

“Eating a typical Western diet – high in processed foods and sugar-sweetened beverages – raises blood glucose and insulin levels, promotes inflammation, and contributes to many neurological disorders, including Alzheimer's disease.”