In a mendelian randomization study, genetically predicted levels of interleukin 6 (IL-6) were associated with neuropsychiatric disorders.
“The postmortem analyses revealed that the overproduction of these pro-inflammatory genes is associated with disorders such as epilepsy, cognitive disorder, schizophrenia, psychotic disorder, and autism spectrum disorder.”
Scientists combine neurocognitive training with aerobic exercise to leverage brain-derived neurotrophic factor and prevent disability in schizophrenia
“[...] > McEwen said that in the second study, the amount of BDNF increased 35 percent in the group that had participated in both cognitive training and exercise -- and half of that increase occurred within the first two weeks of the study.”
Maternal vitamin D deficiency linked to potential developmental disorders, emphasizing a role in dopamine signaling.
“These findings suggest that vitamin D plays multiple roles in dopamine signaling, with potential implications for neurodevelopmental disorders like schizophrenia, ADHD, and autism. They also underscore the importance of adequate maternal vitamin D status during pregnancy.”
Human longevity was associated with decreased levels of genes involved in neural overactivity.
“Healthy brain activity is achieved by maintaining a balance between neural excitation and inhibition. Impairment in this balance is related to many neurological and neurodegenerative disorders, including epilepsy, autism, Parkinson's, Alzheimer's, and schizophrenia.”
Microglial dormancy in depression challenges conventional understanding centered on inflammation, but highlights the immune cell's crucial role in neu
“Microglial changes are common features of many neuropsychiatric disorders, including schizophrenia, autism spectrum disorder, and bipolar disorder. Learn more about microglia suppression in depression in this clip featuring Dr. Charles Raison.”
Immune cells in the brain influence high-order cognitive function but increase the risk of neuropsychiatric disorders.
“Of the species-specific cell types, they noted that one type of microglia was only found in humans, while another was found in both humans and chimpanzees. They also found that microglia express a gene called FOXP2, which is involved in language disorders, schizophrenia, and autism.”
New study explores infection effect on fetal brain development
“These impairments are often manifested in neuropsychiatric disorders such as autism or schizophrenia. Findings from a recent study suggest that interleukin-15 modulates the effects of a simulated viral infection during pregnancy.”
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