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“Furthermore, where we lose pericytes - which are important for dementia prevention - overlaps with the loss of DHA transporters. In this clip, Dr. Axel Montagne discusses how the brain transport of omega-3 DHA may be important for the prevention and possibly as a therapy for dementia.”

“Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects.”

“Other cohorts report null or apparently protective associations that can reflect sick-quitter bias, socioeconomic differences, cardiometabolic health, and drinking pattern. APOE4 may modify vulnerability in some studies, but interactions are inconsistent.”

“Genetic predisposition, altered glucose uptake in the brain, high blood pressure, and other factors can weaken the barrier's integrity, allowing endotoxins and inflammatory immune cells to infiltrate the brain and increasing a person's risk for dementia.”

“Approximately 25 percent of people living in the United States carry a genetic variant of this lipoprotein called APOE4, which is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.”

“Regardless of the limitations of current studies in helping to immediately isolate specific drivers of aging, the clocks should provide a means of assessing cellular age under experimental conditions and make possible the direct testing of hypotheses about the causes of aging or the effectiveness of anti-aging interventions.”

“Prospective human cohorts have reported associations between prenatal BPA measurements and later child behavior, sometimes with sex-specific patterns, but results are inconsistent and residual confounding remains possible.”

“A UK Biobank analysis associated higher reported dietary magnesium with larger gray-matter and hippocampal volumes, but dietary recall and observational design prevent causal conclusions. For migraine prevention, the directly cited clinical evidence is one small randomized crossover trial.”

“The findings support working on several modifiable factors together, while leaving open how much each component contributes and whether these changes prevent an eventual Alzheimer's diagnosis.”

“Preventing dementia requires a lifelong and multipronged approach that involves keeping inflammation (and its aging effects) at bay and making healthy lifestyle choices, such as exercising and consuming omega-3 fatty acids.”