Episode
Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation
“A growing body of evidence suggests that mitophagy is compromised in Parkinson's disease and promotes the accumulation of dysfunctional mitochondria. Impaired mitophagy likely contributes to the aggregation of misfolded proteins, which in turn impairs mitochondrial homeostasis.”
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Increasing protein for longer-term sustainability of a ketogenic diet | Dominic D'Agostino
“A liberalized version of the diet containing more protein and (proportionately) less fat may offer much of the therapeutic potency while being easier to tolerate. This may allow more people to receive the optimal performance and health benefits.”
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Caloric restriction vs higher protein for aging | Dr. Stuart Phillips
“Some animal evidence suggests that low protein intake promotes longevity. However, Dr. Phillips proposes these models may be missing a major element. For example, lab animals are raised and live in a somewhat sterile environment where they are fed on schedule.”
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How the cell prioritizes and targets organelles and protein aggregates for degradation by autophagy
“Autophagy is a cellular defense mechanism that gathers protein aggregates, pathogens, and damaged or dysfunctional organelles into vesicles within the cell and then delivers them for destruction. Subsequently, proteins, fats, carbohydrates, and nucleic acids are released for energy and re-use.”
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Importance of essential amino acids and protein during fasting refeeding | Rhonda Patrick
“After a prolonged fast, in which IGF-1 is deactivated, it's important to consume some protein to promote IGF-1 release. Consuming some carbohydrate, as well, enhances IGF-1 bioavailability to provide optimal results.”
Q&A
Q&A #25: COVID-19 Vaccines—Spike Protein, Ivermectin, & Pregnancy
Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
Q&A
Q&A #36: How Much Protein After 50?—Sources, Timing, & Leucine
Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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