Search results for biomarkers

“Randomized controlled trial finds that reducing food intake lowered metabolic rate during sleep by 10% and reduced DNA damage, a biomarker for aging, by 20% in healthy adults. DNA damage accumulates with age and plays a role in cancer, stem cell dysfunction, and more.”

“Preliminary evidence that insulin resistance may play a role in fibromyalgia. People high HbA1c (a biomarker for long-term blood glucose) were significantly more likely to have fibromyalgia even if they did not have type 2 diabetes.”

“The authors of the study assessed the participants' response to a stressor (public speaking) before and after the interventions, based on biomarkers associated with stress, including adrenocorticotropic hormone (ACTH) and proinflammatory cytokines.”

Dr. Rhonda Patrick discusses fragmented sleep, lipid biomarkers including ApoB and LP(a), coffee makers and bean quality, and choline supplementation.

Biological aging clocks use DNA methylation patterns and other biomarkers to estimate different dimensions of biological aging, including how old the body appears at the molecular level, how quickly aging-related changes are accumulating, and whether lifestyle or medical interventions may be changing the trajectory of aging.

“Half of the participants received the usual care, while the other half received a 20-week intensive lifestyle intervention. The researchers assessed the participants' cognitive and functional performance and measured plasma biomarkers associated with Alzheimer's before and after the intervention.”

“Monitoring the response to cancer treatment is crucial because it informs subsequent therapeutic decisions. Research indicates that liquid biopsy can detect changes in tumor burden earlier than conventional methods, such as imaging or protein biomarkers.”

“The assay can detect within-person changes in autophagic flux, but it remains a research method and is not a validated clinical biomarker of biological aging. Deregulated nutrient sensing The body employs many sensing pathways that detect intra- and extracellular fat, amino acid, and sugar concentrations.”

“Accelerated PhenoAge was linked with higher inflammatory biomarkers (such as C-reactive protein), higher insulin, higher glucose, higher triglycerides, and lower HDL. The DNA methylation PhenoAge acceleration was also linked to known age-related changes in blood cells, such as decreased populations of CD4 and CD8 T-cells and increased granulocytes.”

“But the real changes happened when the participants started the intervention. Regardless of diet, improvements in glucose control biomarkers and inflammation (C-reactive protein) were linked to less brain aging in the hippocampus.”