Search results for small vessel disease

“The glymphatic system – a vast arrangement of cerebrospinal fluid-filled cavities surrounding the small blood vessels in the brain – facilitates the removal of proteins and metabolites from the central nervous system.”

“SARS-CoV2 exploits the angiotensin-converting enzyme 2, or ACE2, receptor to gain entry into cells. The ACE2 receptor is widely distributed among the body's tissues but is particularly abundant in lung alveolar epithelial cells and small intestine enterocytes.”

“Diabetes, hypertension, and smoking can injure blood vessels through chronic metabolic stress, inflammation, and oxidative damage. In the brain, this can impair small vessels, increase stroke risk, and contribute to processes involved in dementia.”

“It performs both a general housekeeping role and a targeted cleansing strategy to maintain cellular health. Autophagy is impaired in Parkinson's disease, reducing clearance of alpha synuclein aggregates and driving neuronal death.”

“MicroCT scans in two mice showed small openings in the lower spine where blood vessels pass between the abdomen and the spinal canal, creating a possible route for that abdominal pressure to reach the brain.”

“"Bisphenol a: an emerging threat to male fertility". Reprod Biol Endocrinol. 2019 Cardiovascular disease There’s growing evidence that microplastics and their associated chemicals—like BPA and phthalates— also have significant impacts on the heart and blood vessels.”

“People with high levels of omega-3 DHA are ~50% less likely to develop Alzheimer's disease compared to people with low levels. Disruption of brain DHA transport via the MFSD2A transporter causes blood-brain barrier breakdown.”

“Maintaining early healthy blood pressure is critical to ensuring the proper functioning of blood vessels in the brain and blood-brain barrier integrity. Cumulative exposure to high blood pressure damages blood vessels and increases dementia risk.”

“Genetic predisposition, altered glucose uptake in the brain, high blood pressure, and other factors can weaken the barrier's integrity, allowing endotoxins and inflammatory immune cells to infiltrate the brain and increasing a person's risk for dementia.”

“As the blood-brain barrier breaks down, whether as a part of aging or neurodegenerative disease, immune cells, inflammatory cytokines, toxic proteins, and red blood cells gain access to the brain from the blood and contribute to cognitive dysfunction.”