Related Episodes for "Type 3 diabetes" — could blood-brain barrier breakdown be the cause? | Axel Montagne, Ph.D.

“00:34:40 - Repeated traumatic brain injury has cumulative neuroinflammatory effects in the brain over years, including amyloid-beta plaque and tau tangle formation. Study. 00:44:00 - A variant of the APOE gene increases risk of developing Alzheimer’s disease as much as 15-fold.”

“New Scientist article. 02:06:10 - Some people, like Tom Cruise and Keanu Reeves, seem to defy aging. 02:08:15 - One 12-ounce can of sugar-sweetened soft drink per day shortened telomere length, corresponding to 4.6 years of biological aging.”

“If we eat carbohydrate-containing foods when melatonin levels are high, our pancreas cannot produce the insulin needed to use the glucose. Therefore, eating too close to bedtime or immediately upon waking, before nightly melatonin levels have declined, may hamper the body's ability to process glucose.”

“Finally, choline is also a precursor for phosphatidylcholine, the major component of all cell membranes, which affects the structure, permeability and function of cells and is particularly important in neurons since it plays a role in general neurotransmission.”

“Dr. Patrick recommends bounded quality checks such as GMP manufacturing and independent testing; she notes that some tested products were below their stated heavy-metal limits, not that lion’s mane products are uniformly contaminated.”

“A preliminary study shows atrophy in olfactory brain regions and areas responsible for learning and memory, after COVID-19 illness, even in those with mild cases. Converging evidence suggests that the long-term impacts of SARS-CoV-2 infection are unknown.”

“The mast cells release pro­inflammatory cytokines and proteases that damage the gut, leading to intestinal permeability, a condition otherwise known as “leaky gut.” This leakiness allows bacteria and bacterial antigens to cross the gut’s inner layer, the epithelium, and activate even more immune cells, leading to more inflammation – a key driver in the aging process.”

“In this brief episode, we learn how restoring our dietary and sleep pattern to one that more closely syncs with those imposed by nature, especially by avoiding eating within 2-3 hours before bed and onset of melatonin production, may improve our health and potentially prolong our healthspan.”

“Another randomized study found better long-term picture-location memory when exercise occurred four hours after learning, showing that timing can shape the result. Dr. Patrick also discusses serotonin and hippocampal neurogenesis as a possible biological link.”

“A proponent of the preventative health value of aggressively collecting data, Dr. Snyder's story is illustrative because, without his tracking of glucose, he may not have realized when the point at which his personal glucose management warranted seeking medical attention, potentially putting him at risk of more long-term deleterious effects.”