Related Episodes for Dr. Dale Bredesen on Preventing and Reversing Alzheimer's Disease

“Approximately 25 percent of people living in the United States carry a genetic variant of this lipoprotein called APOE4, which is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.”

“Inflammation, a downstream consequence of insulin resistance, promotes the formation of reactive oxygen species and other damaging molecules, which can enter the brain via the lymphatic system.”

“Nicotinamide riboside and nicotinamide mononucleotide, molecules commonly referred to as NAD+ "boosters," exert beneficial effects on the brain, especially in the setting of vascular dementia.”

“The findings support working on several modifiable factors together, while leaving open how much each component contributes and whether these changes prevent an eventual Alzheimer's diagnosis.”

“The fact that poor sleep is linked with the aggregation of amyloid-beta plaques in the brain and Alzheimer's disease is not surprising. Although some strategies for improving the quality of sleep among people with Alzheimer's have been identified, this might be too late to turn the tide of cognitive decline.”

“Removing former drinkers from the non-drinker category reveals a different story: One study observed that the lowest risk for cardiovascular disease (i.e., ischemic heart disease) was right below one standard U.S. drink per week — men and women at this level of consumption had an ~18% lower risk compared to nondrinkers.”

“In this Aliquot, sleep scientist Dr. Michael Grandner explains why sleep apnea is so often missed, how these nightly breathing disturbances affect the body, and which treatments can meaningfully improve sleep and long-term health.”

“And one potential strategy for mitigating our risk for Alzheimer's disease as we age is a "cognoscopy" – a battery of assessments that measures some of the key biomarkers associated with the disease and can inform the trajectory of treatment.”

“The decline of deep sleep begins early in life, nearly disappears by age 80, increasing the risk for Alzheimer's disease. These Aliquot segments feature Dr. Charles Raison, a professor of psychiatry, and Dr. Matthew Walker, a professor of neuroscience and psychology.”

“Zinc is an essential nutrient that participates in many biological processes and plays critical roles in immune function, protein synthesis, wound healing, DNA synthesis, cell division, and brain health.”