Related Episodes for The Optimal Creatine Protocol for Strength, Brain, and Longevity | Darren Candow, PhD

“Insulin-like growth factor 1 (IGF-1) plays a role during childhood for growth and continues later in life to have anabolic and neurotrophic effects. IGF-1 is also implicated in contributing to aging and enhancing the growth of cancer after it has been initiated.”

Many of the anabolic effects of growth hormone are thought to be mediated by insulin-like growth factor-1, or IGF-1 (https://www.ncbi.nlm.nih.gov/pubmed/18500379), which is synthesized primarily in the liver but also in skeletal muscle in response to growth hormone.

“Study. 01:43:00 - High animal protein intake was only positively associated with cardiovascular mortality among individuals with at least one unhealthy lifestyle risk factor, such as obesity or sedentary lifestyle. Study.”

“01:52:55 - Environmental enrichment creates epigenetic changes that benefit learning and memory in rodents and these benefits transfer to offspring. Study. 02:05:00 - NASA study showed that gravity influenced expression of genes involved in metastasis.”

“02:03:18 - A recent study measured omega-3 fatty acid levels from both supplemental and dietary sources in blood and found that for every 1 percent increment in omega-3 fatty acid levels there was a 20 percent decreased risk in all-cause mortality.”

“00:34:40 - Repeated traumatic brain injury has cumulative neuroinflammatory effects in the brain over years, including amyloid-beta plaque and tau tangle formation. Study. 00:44:00 - A variant of the APOE gene increases risk of developing Alzheimer’s disease as much as 15-fold.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”

“Finally, choline is also a precursor for phosphatidylcholine, the major component of all cell membranes, which affects the structure, permeability and function of cells and is particularly important in neurons since it plays a role in general neurotransmission.”

“A preliminary study shows atrophy in olfactory brain regions and areas responsible for learning and memory, after COVID-19 illness, even in those with mild cases. Converging evidence suggests that the long-term impacts of SARS-CoV-2 infection are unknown.”

“The mast cells release pro­inflammatory cytokines and proteases that damage the gut, leading to intestinal permeability, a condition otherwise known as “leaky gut.” This leakiness allows bacteria and bacterial antigens to cross the gut’s inner layer, the epithelium, and activate even more immune cells, leading to more inflammation – a key driver in the aging process.”