Related Episodes for Dr. Eric Verdin on Ketogenic Diet, Longevity, Beta-Hydroxybutyrate, HDAC Inhibitors, & NAD+

“Other observational research in women has associated healthier dietary patterns with modestly lower acceleration on PhenoAge and GrimAge, while large prospective studies associate greater fruit and vegetable intake with lower cardiovascular and all-cause mortality.”

“There's a lot of exciting research right now into aging and maximum lifespan, but scientists have really just scratched the surface of the fascinating topic of how to live longer, healthier lives. Relevant Publications Rootzén, Holger, and Dmitrii Zholud.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”

“To keep magnesium levels up, especially if you're active and losing a lot of magnesium through sweating, adding more magnesium-rich foods to your meals or opting for supplements like magnesium glycinate or citrate can make a big difference in maintaining your cell health and overall well-being.”

“The question of whether NAD+ is derived directly from NR or NMN in certain tissues rather than being salvaged from nicotinamide may, in particular, have implications for whether or not oral administration may be hampered in achieving maximal NAD+ status due to the fact that the process of salvaging NAD+ from nicotinamide is subject to feedback inhibition.”

“Mammalian target of rapamycin (mTOR) and insulin-like growth factor-1 (IGF-1) are proteins that play critical roles in two major growth pathways in the human body. The intake of amino acids regulates these two pathways, which must remain in balance to facilitate muscle growth and repair.”

“Continued physical, social, and intellectual engagement offers a practical way to support multiple parts of peakspan throughout later life, while the framework helps people think about function one domain at a time.”

“01:36:35 - How increased muscle mass helps achieve lower blood sugar levels – reducing overall mortality – and the potential for suboptimal glycemic control long before doctors identify it. 01:52:28 - Peter's 80% zone 2 / 20% VO2 max training protocol.”

“Most common graying is strongly related to age and genetics, but selected observations suggest that stress, nutrient status, and cellular energy metabolism can influence pigment in some circumstances.”

“Diamandis and Robbins are a dynamic duo, having paired up with co-author Dr. Robert Hariri to write Life Force, a best-selling book that describes breakthroughs in precision medicine and health technologies that can help people live longer, healthier, more fulfilling lives – in the very near future.”