Related Episodes for Dr. George Church: Rewriting Genomes to Eradicate Disease and Aging

“New Scientist article. 02:06:10 - Some people, like Tom Cruise and Keanu Reeves, seem to defy aging. 02:08:15 - One 12-ounce can of sugar-sweetened soft drink per day shortened telomere length, corresponding to 4.6 years of biological aging.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”

“A later Framingham analysis followed 2,240 adults for 11 years and found that a red-cell fatty acid model including the Omega-3 Index predicted all-cause mortality about as well as a model using several standard cardiovascular risk factors.”

“Alterations in magnesium and oxidative status during chronic emotional stress - Young adults undergoing persistent or intermittent stress like anticipating military conflict) experienced substantial decreases in their overall and plasma magnesium concentrations over three months.”

“If your magnesium levels are inadequate, then your ability to boost mitochondrial number during HIT will be dampened, thus, compromising performance and the mitochondrial mass you would have otherwise gained as a consequence of your hard work and effort.”

“Rumination, the practice of dwelling on external stressors to excess, can set in motion a cascade of hormonal and physiological responses that harm mental and physical health. Meditation has been shown to reduce rumination and its negative effects, however, and influences the gene expression of as many as 500 genes, many of which are in the brain.”

“The mast cells release pro­inflammatory cytokines and proteases that damage the gut, leading to intestinal permeability, a condition otherwise known as “leaky gut.” This leakiness allows bacteria and bacterial antigens to cross the gut’s inner layer, the epithelium, and activate even more immune cells, leading to more inflammation – a key driver in the aging process.”

“Using a Mendelian randomization analysis, scientists determined that people carrying genetic variants associated with low vitamin D levels have higher mortality from respiratory tract infections and higher all-cause mortality.”

“While Dr. Rhonda Patrick’s first video focused primarily on the micronutrients found in the various fruits and vegetables she put in her smoothie, this one, in addition to offering some modest changes on the recipe, instead focuses on the beneficial “hormetic” compounds that are NOT micronutrients.”

“A meta-analysis of resistance-training trials found that protein supplementation produced modest additional gains in strength and fat-free mass, with average fat-free-mass benefit plateauing near 1.62 g/kg/day. This is a group estimate, not a precise requirement for every older adult.”