Related Episodes for Inflammation is a key regulator of lipoprotein metabolism | Ronald Krauss

Dr. Rhonda Patrick discusses fragmented sleep, lipid biomarkers including ApoB and LP(a), coffee makers and bean quality, and choline supplementation.

“Diamandis and Robbins are a dynamic duo, having paired up with co-author Dr. Robert Hariri to write Life Force, a best-selling book that describes breakthroughs in precision medicine and health technologies that can help people live longer, healthier, more fulfilling lives – in the very near future.”

“When most people think about certain lifestyle factors that affect insulin sensitivity and blood glucose levels, they think about macronutrient composition, or calories, or fasting, or exercise (and lack of), but they don’t often think about sleep.”

“Based on findings from more recent studies using stable isotopes, which more accurately assess muscle protein anabolism and catabolism, Dr. Phillips believes that eating 1.2 to 1.6 grams of protein per kilogram of bodyweight (about 0.5 to 0.7 grams per pound) is likely optimal for muscle protein synthesis, especially as one ages.”

“Human trials suggest that alpha-lipoic acid can modestly improve selected lipid measures. A dose-response meta-analysis of 12 studies found reductions in total cholesterol, LDL cholesterol, and triglycerides across doses from 300 to 1,200 milligrams per day.”

“Randomized-trial meta-analysis suggests that properly formulated zinc acetate or zinc gluconate lozenges providing more than 75 milligrams of elemental zinc per day can shorten common-cold duration when started early.”

“Since then, countless studies have tested Pauling's theories about vitamin C, colds, and cancer (and many others), and a substantial body of evidence has emerged, identifying critical roles for vitamin C in immune function, cardiovascular and respiratory health, cognitive development and preservation, and many other aspects of human health.”

“A 2025 meta-analysis found improved quality of life, no clear overall change in ejection fraction, and a borderline improvement in New York Heart Association functional class across a small set of trials.”

“In a controlled five-week crossover trial involving men with prediabetes, an early six-hour eating window with dinner before 3 p.m. improved insulin sensitivity, pancreatic beta-cell responsiveness, blood pressure, oxidative stress, and appetite without causing weight loss.”