Ranked by shared topics, with one result from each original episode.
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“Metformin, a drug commonly used to treat type 2 diabetes, has garnered interest as a longevity compound because it was shown to extend lifespan in some animal models. These effects are variable and seem to depend on the age and gender of the animals, as well as the dose provided.”
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“In this clip, Drs. Levine and Patrick discuss definitions of aging used in science and why biological aging matters to scientists. Dr. Levine shares the hallmarks of aging that help researchers determine someone's biological age, what drives accelerated aging, and what epigenetic modifications such as CpG methylation say about the aging process.”
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“The stability of DNA methylation patterns - in terms of sample reliability - makes the use of epigenetic clock data an attractive tool in the hands of researchers investigating aging around the world.”
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“A study conducted in collaboration with Dr. Stuart Phillips revealed that older pre-diabetic individuals who took fewer than a thousand steps daily for two weeks experienced lasting decreases in protein synthesis and insulin sensitivity, which did not fully recover even after resuming regular activity.”
“Rebuilding muscle relies on proper nutrition and exercise, but aging reduces the body's response to both. Extended periods of inactivity, such as post-surgery or during illness, can rapidly deplete muscle mass, especially in older people, potentially pushing them into a "catabolic crisis."”
“Scientists are exploring a wide range of cutting-edge therapies aimed at understanding and manipulating the complex processes underlying these hallmarks, including epigenetic aging clocks and pluripotent stem cells.”
“In part I of this two-part series on the future of aging research, we discussed the hallmarks of aging and the cutting-edge therapies aimed at understanding and manipulating the complex processes underlying these hallmarks, including epigenetic aging clocks and pluripotent stem cells.”
“A May 2025 Nature paper showed taurine uptake may fuel aggressive myeloid leukemias in laboratory and mouse models, illustrating how nutrients beneficial to healthy tissues may also feed certain cancers.”
“In this Aliquot, Drs. Peter Attia, Stuart Phillips, Morgan Levine, Brad Schoenfeld, Michael Snyder, Valter Longo, Martin Gibala, George Church, as well as Kevin and Darya Rose and myself, share our strategies for finding our fitness.”
“Martin Gibala, Bill Harris, and Peter Attia about three proven ways to promote health and longevity: boosting cardiorespiratory fitness, ensuring you're getting plenty of omega-3 fatty acids, and maintaining healthy blood glucose levels.”