Related Episodes for Mendelian randomization, a powerful tool to assess the effects of low vitamin D | Roger Seheult

“Manipulation of cellular levels of NAD+ as a strategy for slowing aging "We’ve shown that NMN and others have shown for NR that it also helps with blood flow and actually mimics exercise and regrows the vascular system.” - David Sinclair, Ph.D. As we age, however, the NAD+ levels in our bodies decline, reducing resveratrol's potency.”

“Genetic factors can impact plasma lipoprotein levels and the risk of coronary artery disease. Genes associated with elevated low-density lipoprotein (LDL) cholesterol levels have also been associated with increased heart disease risk, suggesting a causal relationship.”

“While some forms of Parkinson's disease are genetic, most cases involve a complex interaction between genetic and environmental risk factors. In the early 1980s, intravenous drug users inadvertently injected a contaminated drug and developed parkinsonian symptoms overnight.”

“Sure, those dates on the calendar pass at the same rate for everybody, but some people appear to age slower (or faster) than others – with vastly different age-related physical changes and disease risks.”

“Geneticists like Dr. George Church, believe gene drives could be used to eliminate pathogens carried by insects, such as malaria, which is carried by a small number of mosquito species, or Lyme disease, which is carried by deer ticks.”

“Osimertinib, for example, improved five-year survival among patients with resected EGFR-mutated lung cancer, while CAR-T therapy has produced durable remissions in some children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia.”

“Family-controlled research provides another view. A Swedish cohort of 2.48 million children found small associations in conventional models, but the estimates moved to the null when siblings with different prenatal exposure were compared.”

“Rumination, the practice of dwelling on external stressors to excess, can set in motion a cascade of hormonal and physiological responses that harm mental and physical health. Meditation has been shown to reduce rumination and its negative effects, however, and influences the gene expression of as many as 500 genes, many of which are in the brain.”

“Gene polymorphisms, small changes in an organism's DNA sequence, can affect the absorption and metabolism of nutrients, including vitamins and minerals. A polymorphism in the MTHFR gene that decreases enzyme activity leads to inefficient folate metabolism.”