Related Episodes for The effect of vigorous exercise on fat oxidation and mitochondria | Dr. Martin Gibala

“Liberalizing the diet by altering protein, fat, and fiber intake may make the diet more tolerable. For those who have difficulty reaching and sustaining ketosis, ketone supplementation may be beneficial, but their use might interfere with weight loss.”

“While animal-derived protein has the advantage of containing more amino acids that promote hypertrophy – particularly leucine – research suggests that plant-based proteins can be more viable for supporting muscle than previously thought.”

“But implementing a ketogenic diet is challenging. In this Aliquot, Dr. Dominic D'Agostino explains how to avoid side effects on a ketogenic diet, provides valuable pointers for success, and explains how the diet might help preserve muscle mass.”

Hormesis is a compensatory defense response to a stressor that conditions the body against future stressors. Heat exposure – from sauna use, hot tubs, or eve...

“A four-week pilot study in people with type 2 diabetes reported improved insulin-stimulated glucose disposal after oral alpha-lipoic acid, while a three-week randomized trial found that intravenous 600 milligrams per day reduced diabetic neuropathy symptoms.”

“In this clip, Dr. Dominic D'Agostino explains the interrelationship between ketones and lactate as sources of energy for the brain and the role ketones may have in reducing oxidative stress through greater energetic efficiency.”

“In the modern-day with no imposed fasting, these cycles of renewal may remain dormant. In this clip, Dr. Valter Longo discusses how cellular repair mechanisms may have evolved during times of fasting, but are latent in times of food abundance.”

“In this clip from his FoundMyFitness interview with Dr. Rhonda Patrick, Dr. Derya Unutmaz presents an optimistic vision in which AI, biotechnology, and rapidly improving treatments help more people remain healthy long enough to benefit from the next generation of therapies.”

“New Scientist article. 02:06:10 - Some people, like Tom Cruise and Keanu Reeves, seem to defy aging. 02:08:15 - One 12-ounce can of sugar-sweetened soft drink per day shortened telomere length, corresponding to 4.6 years of biological aging.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”