Related Episodes for Does the omega-6 to omega-3 ratio matter?

Dr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging.

“Dr. Patrick explains some of the early evidence that suggests the value prolonged fasting (48+ hours) may have from the standpoint of tissue rejuvenation and healthspan maintenance, as well as relevance for other more specific conditions.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“Many people may find the prolonged fast too onerous, but the fasting-mimicking diet, an approach that recapitulates many of the same effects of prolonged fasting with a hyper-low calorie, low protein, higher fat diet stretched out over a longer interval of five days, may offer a more palatable strategy for activating autophagy.”

“Additionally, blood flow restriction training offers a method to achieve metabolic stress without high-impact forces, presenting a potential solution for those wary of joint stress. In this clip, Dr. Martin Gibala examines how different HIIT exercises influence bone growth and joint issues.”

“Although many seed vendors provide quality seeds that are free of pesticides and have high germination rates, determining the glucoraphanin content in broccoli seeds requires laboratory analysis that may be cost-prohibitive for most home growers.”

“A systematic review in older adults linked Mediterranean dietary patterns with lower inflammatory markers, while a meta-analysis of randomized trials found that vitamin D supplementation reduced acute respiratory infection risk overall, with the strongest protection among people who were very deficient and received regular doses.”

“A meta-analysis of seven randomized trials involving 182 participants found that high-intensity interval training improved flow-mediated dilation by 4.31%, compared with 2.15% after moderate-intensity continuous training, with a 2.26-percentage-point advantage between groups.”

“When starting a ketogenic diet, it is important to track macronutrients, calories, and relevant biomarkers. Dr. D'Agostino notes that breath acetone is a suitable way to measure ketones if you are interested in fat loss since all the carbons in breath acetone derive from fat molecules.”

“A meta-analysis of 19 randomized trials involving 1,683 participants found modest average improvements, including about seven minutes less time to fall asleep and eight minutes more total sleep. Product quality can make dose selection difficult.”