Related Episodes for Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging

Dr. Rhonda Patrick reviews the evidence for nattokinase, how oat beta-glucans may aid with PFAS excretion, and HRT for APOE4 carriers.

“When most people think about certain lifestyle factors that affect insulin sensitivity and blood glucose levels, they think about macronutrient composition, or calories, or fasting, or exercise (and lack of), but they don’t often think about sleep.”

“In contrast, a five-week trial in 181 people with diabetic polyneuropathy found that oral alpha-lipoic acid improved symptom scores, with more nausea, vomiting, and vertigo at higher doses. PQQ has a much smaller human evidence base.”

“Since then, countless studies have tested Pauling's theories about vitamin C, colds, and cancer (and many others), and a substantial body of evidence has emerged, identifying critical roles for vitamin C in immune function, cardiovascular and respiratory health, cognitive development and preservation, and many other aspects of human health.”

“A network meta-analysis of 84 randomized trials found that aerobic exercise, HIIT, combined training, and resistance training alone all reduced visceral fat, while a separate meta-analysis found a modest reduction from resistance training across 34 studies.”

“In a controlled five-week crossover trial involving men with prediabetes, an early six-hour eating window with dinner before 3 p.m. improved insulin sensitivity, pancreatic beta-cell responsiveness, blood pressure, oxidative stress, and appetite without causing weight loss.”