Q&A #51 with Dr. Rhonda Patrick (9/2/23)

Posted on September 7th 2023 (over 1 year)

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Dr. Rhonda Patrick explores growth hormone secretagogues, spermidine's longevity role, methylene blue, whey protein, and solutions for scar tissue in a Q&A.

Beginning of Q&A
Q: What are the pros and cons of using MK677 and sermorelin as growth hormone secretagogues? 1, 2, 3, 4
Q: Is spermidine recognized as a longevity supplement? 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
Q: What are Rhonda's thoughts on David Sinclair's Vitality supplement? 1, 2
Q: Can methylene blue aid in prolonging life and preventing Alzheimer's disease? 1, 2, 3, 4
Q: Has Rhonda reviewed the MedCram video on photobiomodulation and long COVID?
Q: Is there any value in repeating the 23andMe test?
Q: Which is better whey protein isolate or concentrate? 1
Q: Is using an electrolyte supplement necessary after a sauna session? 1, 2, 3
Q: Why does Rhonda use retinol or vitamin C only once a week? 1
Q: Which supplements decrease the benefits of exercise or sauna? 1
Q: Does sipping lemon juice after meals reduce glucose spikes? 1
Q: What does it mean to take a supplement with fat?
Q: When is the best time to use the sauna? 1
Q: Can anything delay menopause or prolong fertility? 1, 2
Q: What is Rhonda's opinion on Brian Johnson's claim to have the greatest percentage of age reversal in the history of humanity? 1
Q: What is Rhonda's opinion on the claim that berberine is overhyped? 1, 2
Q: How does consuming psyllium husk near mealtimes affect nutrient absorption? 1, 2, 3, 4
Q: Are there natural ways to reduce scar tissue? 1, 2
Q: Is phosphatidylcholine a suitable choline source? 1
Q: What amounts of DHA, EPA, and other omega-3s does Rhonda take?
Q: Is it worthwhile to bank placenta? 1, 2
Q: Is it safe to order omega-3 supplements in summer considering the risk of oxidation? 1

This timeline is available in markdown format

Choline

An essential nutrient involved in a wide range of physiological functions, including neurotransmission, lipid metabolism, and cell membrane composition and repair. Humans can produce some choline in the liver, but most people need to consume choline in the diet to prevent deficiency. Dietary sources of choline include meat, eggs, fish, nuts, and cruciferous vegetables, among others. Evidence suggests that prenatal choline supplementation improves attention span in children.^[1]

^ 34962672

View choline topic

Growth hormone

A peptide (non-steroid) hormone produced by the pituitary gland. Growth hormone promotes longitudinal growth in children and adolescents and plays important roles in metabolism and muscle growth throughout life. The production of growth hormone diminishes with aging.^[1]

^ Corpas, Emiliano; Harman, S. Mitchell; Blackman, Marc R. (1993). Human Growth Hormone And Human Aging Endocrine Reviews 14, 1.

Longevity Compounds

A compound that can increase the lifespan of an organism such as rapamycin and resveratrol.

Menopause

The cessation of a female's menstrual cycle and an indicator of the loss of reproductive capacity. Menopause typically occurs around the age of 52 years and may increase the risk for age-related disease and premature death.^[1]

^ Finch CE (2014). The menopause and aging, a comparative perspective. J Steroid Biochem Mol Biol 142, .

Omega-3 fatty acid

A type of polyunsaturated fat that is essential for human health. Omega-3 fatty acids influence cell membrane integrity and affect the function of membrane-bound cellular receptors. They participate in pathways involved in the biosynthesis of hormones that regulate blood clotting, contraction and relaxation of artery walls, and inflammation. They have been shown to help prevent heart disease and stroke, may help control lupus, eczema, and rheumatoid arthritis, and may play protective roles in cancer and other conditions. Omega-3 fatty acids include alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). ALA is found mainly in plant oils such as flaxseed, soybean, and canola oils. DHA and EPA are found in fish and other seafood. The human body can convert some ALA into EPA and then to DHA, but the efficiency of the process varies between individuals.

View omega-3 fatty acids topic

Placenta

A temporary organ that supports fetal respiration and growth during pregnancy. The placenta is a rich reservoir of stem cells, including trophoblastic, hematopoietic, epithelial, and mesenchymal stem cells, which can be harvested for therapeutic use for an extensive catalog of diseases, as well as slowing or preventing the deleterious effects of aging.^[1]

^ Sebire, Neil J; Deprest, Jan; David, Anna L; De Coppi, Paolo; V. Guillot, Pascale; Pipino, Caterina, et al. (2012). Placenta As A Reservoir Of Stem Cells: An Underutilized Resource? British Medical Bulletin 105, 1.

Sauna

An enclosed space where one bathes in short-term passive exposure to extreme heat. This exposure elicits mild hyperthermia – an increase in the body's core temperature – that induces a thermoregulatory response involving neuroendocrine, cardiovascular, and cytoprotective mechanisms that work together to restore homeostasis and condition the body for future heat stressors. Sauna use is associated with reduced risk of many chronic diseases, including cardiovascular disease, neurodegenerative disorders, and depression, among others.

View sauna topic

Spermidine

A polyamine (an organic compound having more than two amino groups) named for having been isolated in semen. Spermidine has since been found in a variety of different tissue types, as well as foods. It is best known for its role as a potential autophagy and longevity promoter with its effects having been demonstrated in yeast, flies, worms, and human immune cells.^[1]

↓ Acetyltransferase activity (especially EP300) → ↓ cytosolic Acetyl CoA → Autophagy

↓ mitochondrial transmembrane potential → ↑ ubiquitination → mitophagy (preferentially targeted)

^ Hartl, Regina; Megalou, Evgenia; Laun, Peter; Heeren, Gino; Breitenbach, Michael; Grubeck-Loebenstein, Beatrix, et al. (2009). Induction Of Autophagy By Spermidine Promotes Longevity Nature 11, 11.

Whey protein

The primary protein found in dairy products. Whey protein is often concentrated and sold as a dietary supplement to increase protein intake and promote lean body mass accretion.^[1]

^ Ballard, Kevin D; Earp, Jacob E; Bruno, Richard; Kellogg, M D; Dunn-Lewis, Courtenay; Aristizabal, J C, et al. (2013). Whey Protein Supplementation During Resistance Training Augments Lean Body Mass Journal Of The American College Of Nutrition 32, 2.

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