What FoundMyFitness Has Covered
PremiumGenetic engineering spans population-level disease control, agricultural sustainability, and experimental medicine. Gene drives can bias inheritance so selected alleles spread through insect or animal populations, raising the possibility of reducing vectors for malaria or Lyme disease.…
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Based on available source text from 9 of the first 10 results.
Episode
Dr. George Church: Rewriting Genomes to Eradicate Disease and Aging
“01:41:33 - How a type of genetic engineering called Gene Drive, a technique so powerful that it bends the laws of Mendelian inheritance, may make insects or animals unable to carry diseases that affect humans, such as malaria or Lyme disease.”
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Will gene drive eliminate Lyme disease and malaria? │ Dr. George Church
“Gene drive is a natural process and a tool used in genetic engineering that spreads a specific set of genes throughout a population of organisms. While normally, the chance of inheriting a specific gene from your mother or father is 50%, gene drives increase the likelihood of inheritance, increasing the density of alleles in a family over generations.”
Caloric restriction
“Rhesus monkeys share many genetic and physiological characteristics with humans and are good models for studying aging and disease in humans. Despite the critical differences in the findings from these studies, substantial evidence suggests that caloric restriction may serve as a means to increase human healthspan.”
Omega-3 fatty acids
“In other words, genetic engineering of plants that produce high-yield and high-quality EPA and DHA may offer yet another strategy to meet the growing needs of people that prefer to avoid animal-based products or are concerned about sustainability.”
Neu5Gc
“For example, a large, population-based study that drew data from more than 170,000 men and women between the ages of 30 and 75 years showed that animal protein intake was associated with increased death rates only when the participants had at least one unhealthy lifestyle risk factor such as smoking, heavy alcohol consumption, physical inactivity, or being overweight or obese.”
Epigenetic aging clocks
“They do show how AI-designed proteins can move from computational proposals to wet-lab validation, an example discussed in Dr. Derya Unutmaz's FoundMyFitness interview. Epigenetic aging determined by genetic and lifestyle factors Some individuals may be genetically predisposed to a slower overall clock rate.”
Liquid biopsy (cancer screening)
“Liquid biopsy correctly identified 70 percent of cancer patients and 87 percent of healthy controls. The accuracy improved when the reviewers included only studies with modern assessments of genetic and epigenetic irregularities in cfDNA.”
Brain-derived neurotrophic factor (BDNF)
“Several genetic variants of BDNF were evaluated, and while the Val66Met variant was associated with women with eating disorders, other variants showed an even stronger association.”
Quercetin
“Similarly, the authors of a study in mice created a genetic model to demonstrate the health-promoting effects of clearing senescent cells. They engineered the mice to carry a gene that, when activated with a drug, would selectively kill senescent cells.”
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