What FoundMyFitness Has Covered
PremiumNeurogenesis is the formation of new neurons: it is essential during embryonic development and appears to continue in select brain regions throughout human life. In adults, hippocampal neurogenesis is discussed in relation to memory, mood, and…
Your Premium Brief connects insights across FoundMyFitness to help you see the bigger picture.
Episode
Hyperthermic Conditioning for Hypertrophy, Endurance, and Neurogenesis
“Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass. She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.”
Clip
How Aerobic Exercise Timing Can Support Memory
“Another randomized study found better long-term picture-location memory when exercise occurred four hours after learning, showing that timing can shape the result. Dr. Patrick also discusses serotonin and hippocampal neurogenesis as a possible biological link.”
Episode
"Hacking Your Genes" at SF Nerd Nite
“Dr. Rhonda Patrick talks at SF Nerd Nite about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.”
Clip
IGF-1 and its role in diabetes and Alzheimer's | Peter Attia
“Preclinical research suggests that this can be accomplished by feeding animals an IGF-1 promoting diet, in conjunction with antibodies against the IGF-1 receptor which are unable to cross the blood-brain barrier. In this clip, Dr. Peter Attia addresses the challenges of balancing IGF-1 levels in the brain and body to promote neurogenesis without stimulating cancer.”
Depression
“Establishing these new circuits depends upon adequate neurogenesis, the process of forming new neurons. Neurogenesis is essential during embryonic development but continues in certain brain regions throughout the human lifespan.”
Butyrate
“Eight weeks after the transplant, the mice that received microbial samples from the old mice demonstrated increased neurogenesis – the process of forming new neurons – in the hippocampus region of their brains.”
Beta-hydroxybutyrate
“These changes in gene expression enhanced multiple markers of neurogenesis and improved performance during the water maze test. Mice eating a regular diet that received daily BHB injections achieved similar serum BHB levels as mice eating a ketogenic diet and experienced the same gains in neurogenesis.”
Psilocybin
“These experiences, mediated by decreased activity in the brain's default mode network and enhanced neurogenesis, lead to lasting improvements in mood, behavior, and openness, positioning psilocybin as a promising tool for mental health and potentially broader therapeutic applications, though its Schedule I status underscores the need for cautious, regulated use.”
Brain-derived neurotrophic factor (BDNF)
“DHF treatment has achieved positive results in many animal models of disease and injury. Some of these are described here. Mouse models of radiation therapy show a loss of hippocampal BDNF expression and cognitive impairments consistent with reduced neurogenesis.”
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