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“Other research indicates that metformin inhibits the exercise-induced improvements in mitochondrial respiration and limits gains in lean body mass. In this clip, Dr. Rhonda Patrick describes the many open questions that remain regarding the interaction between metformin and exercise at the molecular level.”

“Dr. Patrick describes her own 10-gram baseline and occasional 20- to 25-gram use during travel or sleep loss as a personal extrapolation. This clip is excerpted, with permission, from Dr. Rhonda Patrick’s appearance on the Jack Neel Podcast.”

“Clinical symptoms of magnesium deficiency are unlikely, but long term insufficiency can lead to the accumulation of DNA damage over time, which is associated with the diseases of aging. In this clip, Dr. Rhonda Patrick talks about the importance of obtaining adequate magnesium in the diet.”

“While sulforaphane is available in supplement form, it is derived naturally from a variety of cruciferous vegetables such as Brussels sprouts, kale, and mustard greens, with the highest quantities available from broccoli sprouts.”

“For example, time-restricted eating within a 6-hour window without reducing calories or losing weight improves insulin sensitivity, beta cell function, blood pressure, oxidative stress and reduces evening appetite. Dr. Satchin Panda has discussed many benefits of time-restricted eating a couple of times on my podcast.”

“I talk more about the relationship between vitamin D and human aging in this video: https://www.youtube.com/watch?v=uc815fQn8iY I also elaborate on vitamin D supplementation, dose, bioavailability, and more in this short audio-only podcast…”

“Podcast interview: Jed Fahey, ScD, on Isothiocyanates, the Nrf2 Pathway, Moringa, & Sulforaphane Supplementation. Podcast interview: New Omega-3, sulforaphane research, and more! [Dr. Rhonda Patrick on the Kevin Rose Show].”

“Metformin, a drug commonly used to treat type 2 diabetes, has garnered interest as a longevity compound because it was shown to extend lifespan in some animal models. These effects are variable and seem to depend on the age and gender of the animals, as well as the dose provided.”

“Whereas several interventional human trials have revealed that people who obtained sulforaphane from Brussels sprouts experienced increases in the body's antioxidant systems and reductions in oxidative DNA damage, an in vitro study showed that high concentrations of sulforaphane added to cells in a petri dish increased DNA damage.”

“The phospholipid form of DHA, abundant in fish roe, directs DHA into the brain via active transport, thus bypassing the reliance on passive diffusion. In this clip, Dr. Rhonda Patrick discusses DHA bioavailability and describes her personal DHA regimen, which includes dietary and supplemental sources of omega-3 fatty acids.”