Search results for epigenetics

“This episode covers: Effects on Aging & Longevity Key insights: Coffee consumption slows biological aging by reducing epigenetic age. Observational studies consistently show that regular coffee drinkers display younger epigenetic signatures compared to non-coffee drinkers.”

“Methyl donors interact with the methyl carrier, S-adenosyl-L-methionine (SAM) and methylation enzymes to complete the transfer of a methyl group from the donor to a target protein, lipid, or nucleic acid. Methylation of nucleic acids in DNA and ribonucleic acids in RNA is necessary for epigenetic modifications and gene expression.”

“looking forward to (hopefully) doing a podcast with an expert on telomere research soon! Folate is required to make precursors for the DNA nucleotide, thymine, and for methyl groups, which play a role in epigenetics. Leafy greens are high in folate so eat your spinach!”

“The vitamin A activates the enzyme (called TET) that removes methyl groups from DNA and vitamin C is a cofactor for the enzyme. This not only has relevance for reprogramming adult cells into stem cells, it is also important for certain cancers such as acute promyelocytic leukemia, which abnormal methylation plays a role in malignancy.”

“Dr. Verdin's laboratory focuses on the role of epigenetic regulators in the aging process, the role of metabolism and diet in aging and on the chronic diseases of aging, including Alzheimer’s, proteins that play a central role in linking caloric restriction to increased healthspan, and more recently a topic near and dear to many of you, ketogenesis.”

“There was an interesting study published last year showing that obesity causes epigenetic changes and decreases activation of genes involved in learning and memory in humans. Obese men had sperm DNA that is different from sperm DNA in lean men in 300 genes and many are in the brain affecting learning/memory.”

“Steve Horvath, Ph.D., Sc.D. - geroscientist and computational biologist who developed the epigenetic clock, a DNA-methylation-based measure of aging. Shinya Yamanaka, M.D., Ph.D. - Nobel laureate whose discovery showed that mature cells can be reprogrammed into induced pluripotent stem cells.”

“The importance of omega-3 fatty acids. Stem cells and aging: what this means for lifespan. Diet and epigenetics and how this relates to aging.”