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Diagnostics are moving toward earlier, more biologically informed detection, while clinical judgment and established criteria remain central. Blood, cerebrospinal-fluid, and sensitive MRI biomarkers may identify vascular abnormalities in cognitively normal people, and emerging Alzheimer’s biomarkers are…

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Depression

Oct 7, 2026

“Clinicians diagnose depression as major depressive disorder based on a set of diagnostic criteria including one of two primary symptoms – depressed mood (e.g., sadness, irritability) and/or anhedonia (i.e., loss of interest or pleasure in doing things) – and four or more secondary symptoms – appetite or weight changes; sleep difficulties (e.g., insomnia or sleeping too much)…”

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