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“Cellular senescence is the condition or process of deterioration that occurs with age. Senescent cells produce a variety of factors believed to contribute to the aging process. Some scientists have posited that removal of senescent cells would naturally slow aging.”

“Nausea, diarrhea, constipation, vomiting, abdominal symptoms, and treatment discontinuation are important adverse effects and were more common with active drugs than placebo. Major weight loss can also reduce DEXA-measured lean mass; DEXA does not directly measure skeletal muscle, but low protein intake and lack of resistance training increase concern.”

“Researchers studying the psychedelic compound psilocybin and its potential effects on depression observed that a single exposure in humans induced a powerful anti-depressive response that persisted for six months or longer.”

“However the more harmful small, dense LDL is not removed as well as the benign larger LDL. In this clip, Dr. Krauss discusses how statins reduce the risk of cardiovascular disease and potential for better drugs in the future.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“Dr. Montagne's animal research demonstrated that blocking cyclophilin A partially restored vascular function and cognition, suggesting that targeting the blood-brain barrier could be a promising avenue for Alzheimer's treatment.”

Dr. Rhonda Patrick discusses her supplement routine, Neu5Gc risks, Repatha and diabetes, heat stress, osteoporosis in men, and plyometrics.

“In this clip, Dr. Valter Longo discusses the origin of the fasting-mimicking diet and a possible future which may lean away from a drug-centered mentality to one which allows the body to heal itself.”

“Long-term melanoma data show that checkpoint therapy can produce durable survival gains in selected patients, illustrating how immune-based treatment has changed outcomes for some cancers. Targeted drugs and engineered immune cells offer additional ways to match treatment to a tumor.”

“A trial of the investigational drug bimagrumab increased lean mass in older adults with sarcopenia, showing how researchers can target one important feature of physical resilience while continuing to study functional outcomes.”