Q&A #71 with Dr. Rhonda Patrick (6/7/25)
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In this Q&A, Dr. Rhonda Patrick discusses her current supplement routine, if heat exposure accelerates biological aging, PCSK9 inhibitors, Neu5Gc in meat, and more. Timestamps include:
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What supplements do you take and when?
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Does heat stress speed up epigenetic aging?
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Do cholesterol-lowering medications increase diabetes risk?
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What should men know about osteoporosis risk?
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Can plyometrics replace strength training?
Does heat exposure accelerate biological aging?
Extreme ambient heat can feel miserable and even pose acute health risks, but could long-term exposure also speed up biological aging? A recent study explored exactly that.
Epigenetic evidence links sustained ambient heat to faster aging
Researchers analyzed blood samples from roughly 3,700 older adults across the United States.[1] To pinpoint biological age, they utilized DNA methylation clocks, which are tools measuring chemical markers (DNA methylation) that predictably change as we age. These markers reveal a person's "epigenetic age", widely accepted as an indicator of biological aging independent of chronological age.
- ^ Choi, Eun Young; Ailshire, Jennifer A. (2025). Ambient Outdoor Heat And Accelerated Epigenetic Aging Among Older Adults In The US Science Advances 11, 9.
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Beginning of Q&A
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Q: What supplements do you take and when? 1
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Q: Does hot coffee degrade creatine? 1
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Q: Is taurine linked to cancer risk? 1
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Q: Why did you lower your omega-3 dose? 1
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Q: What type of creatine do you take and do you combine it with protein?
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Q: How do you choose a simple-ingredient protein powder?
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Q: Which high-polyphenol olive oils are best for APOE4 carriers? 1
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Q: Should you avoid greens powders like AG1 due to lead? 1
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Q: What probiotics do you take?
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Q: Why did you switch your ubiquinol brand? 1
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Q: Can you get too much sulforaphane? 1
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Q: Is Creapure the best form of creatine? 1
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Q: Is chronic Nrf2 activation harmful? 1
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Q: Can beta-alanine and creatine be used together? 1
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Q: Does ezetimibe affect blood glucose levels? 1
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Q: What xylitol gum did you use during pregnancy?
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Q: How do you prevent fish oil burps?
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Q: Is there lead in hydroxyapatite, a toothpaste ingredient?
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Q: Are supplements available in glass containers?
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Q: Can Repatha replace statins if cost isn't an issue? 1
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Q: Does a Mediterranean diet minimize Neu5Gc? 1
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Q: Is CocoaVia safe in dark plastic containers? 1
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Q: What fitness apps do you use?
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Watch previously recorded Q&As with Dr. Rhonda Patrick
Q&A #75 with Dr. Rhonda Patrick (11/01/25)
Dr. Rhonda Patrick discusses joint aging prevention, avoiding heavy metals in protein, reducing migraines, nicotinamide for skin, and minimizing jet lag.
Q&A #74 with Dr. Rhonda Patrick (10/11/25)
Dr. Rhonda Patrick discusses stroke risk, eczema, immune resilience, her new smoothie recipe, and whether everyone should cut out gluten.
Q&A #73 with Dr. Rhonda Patrick (8/16/25)
Dr. Rhonda Patrick discusses iron imbalances, urolithin A, NAD+ boosters, vitamin K2 and hormone replacement therapy in women.
Q&A #72 with Dr. Rhonda Patrick (7/19/25)
Dr. Rhonda Patrick discusses fragmented sleep, lipid biomarkers including ApoB and LP(a), coffee makers and bean quality, and choline supplementation.
Q&A #70 with Dr. Rhonda Patrick (5/3/25)
Dr. Rhonda Patrick discusses cancer prevention, linoleic acid, shingles vaccine and dementia, creatine's kidney effects, and shares her overnight oats recipe.