Search results for insulin resistance

“The team found that a chemical compound called GW1516 (GW) similarly activated PPARD, replicating the weight control and insulin responsiveness in normal mice that had been seen in the engineered ones. [...] > Mice in the control group could run about 160 minutes before exhaustion.”

“HOMA-IR, a surrogate marker for insulin resistance based on fasting glucose and insulin, also improved. Lower values generally indicate better insulin sensitivity, meaning that the body responds more effectively to insulin and needs less of it to manage blood sugar.”

“Insulin resistance fell with the combined strategy versus control and vitamin D alone; both single interventions also beat control. Fasting glucose decreased with the combined approach compared with control.”

“The investigators found that participants who were exposed to room light conditions during sleep had increased nighttime heart rate, decreased heart rate variability, and increased morning insulin resistance, compared to when they slept in a dark room.”

“eTRE improves insulin sensitivity, beta-cell function, blood pressure, and oxidative stress independent of weight loss. Furthermore, eTRE appears to be superior to late (conventional) TRE for improving insulin resistance, glucose metabolism, blood pressure, and weight loss.”

“A growing body of scientific evidence suggests that there is a correlation between Alzheimer's disease, insulin resistance, and inflammation. Inflammation, a downstream consequence of insulin resistance, promotes the formation of reactive oxygen species and other damaging molecules, which can enter the brain via the lymphatic system.”

“However, several studies have established causation showing that sleep duration is a major determinant of insulin sensitivity. For example, studies that have shown that reductions in sleep duration over multiple nights result in impaired glucose tolerance and insulin resistance in healthy individuals.”

“Dr. Rhonda Patrick also asks how one disrupted night and next-morning caffeine affect glucose. In a small crossover study, fragmented sleep alone did not worsen the morning glucose test, but about 300 milligrams of caffeine before the test increased glucose and insulin responses.”

“Visceral fat is a highly metabolically active form of fat that accumulates deep within the abdomen around organs such as the liver and pancreas. Compared with subcutaneous fat, it releases greater amounts of free fatty acids and secretes inflammatory molecules that contribute to insulin resistance and metabolic disease.”

“Visceral fat is stored around internal organs and contributes to insulin resistance and cardiometabolic risk through fatty-acid delivery, inflammatory signaling, and adipokines. In this clip from Dr. Rhonda Patrick's appearance on The Diary Of A CEO, she explains that sustained weight loss and regular exercise can reduce this metabolically active fat.”