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“The questions in this episode represent what is actually just a small fraction of the many interesting questions submitted from subscribers to my newsletter regarding the on-going COVID-19 pandemic. Hundreds of questions were submitted, ultimately laying the ground work for not just one, but two episodes.”

“The mortality-reducing effects of metformin in people with type 2 diabetes have recently been called into question, however (described in detail below). Cognitive decline & mental health Some evidence suggests that metformin may prevent cognitive losses or improve mental health status.”

“This study involved 1,024 participants with an average age of 81—82% of whom carried the APOE e4 allele (the number one genetic risk factor for developing late-life Alzheimer's disease. The participants were given a dietary assessment that included questions about their habitual egg intake.”

“Every four years, they completed food frequency questionnaires that included questions about their dietary patterns. A subset of approximately 41,000 participants provided information about their beverage intake during their teen years.”

“It does not mean they will die at 58. GrimAge is one of the strongest clocks for mortality risk and disease-risk prediction, especially when the question is not "what is the pace of aging?" but "how much long-term risk is encoded in this blood methylation profile?"”

“Although the treatment group did exhibit better cognitive test performance than the placebo group, this study raises questions about causation and whether the observed benefits were attributable to magnesium threonate, the vitamins, phosphatidylserine, or a blend of these components.”

“Carbohydrate needs therefore depend on context. The relevant question is not simply whether a diet is "low carb," but whether carbohydrate intake and timing match the intensity, duration, and recovery demands of training.”

“Some of the research seems promising despite study heterogeneity and potential conflicts of interest. Therefore, it’s a natural question to speculate what consumer devices might produce some of the effects described above.”

“The findings from this study may have relevance for dietary interventions to maintain or improve brain health. Link to full study. Frequently asked questions What dietary and lifestyle factors can improve symptoms of leaky gut (i.e., increased intestinal permeability)?”

“In this 45-minute podcast, Dr. Patrick answers some of the most popular questions related to fasting, including: What effects coffee, supplements, and amino acids have on fasting. Whether one method of fasting is more beneficial than others.”