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Dr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging.

“BFR training protocols include a frequency of 2-3 times per week, occlusion pressure of 40-80% depending on the limb, using 2 exercises per muscle group, repetition schemes, wear times of 10-20 minutes, loads of 20-50% of 1 rep max, and a tempo of 1-2 seconds for both concentric and eccentric.”

“Circulating LPS can also bind to lipoproteins, facilitating their absorption in the liver during LDL recycling, effectively removing LPS from circulation and lowering systemic inflammation – a phenomenon demonstrated mechanistically with statins that increase lipoprotein recycling by increasing LDL receptors.”

“More importantly, however, these effects were sustained – even after several months – demonstrating that sulforaphane did not exhaust the body's capacity to protect itself from environmental threats and suggesting that regular consumption of sulforaphane in foods or dietary supplements provides a kind of nutritional "seatbelt" that protects against future toxic exposures.”

“Alterations in magnesium and oxidative status during chronic emotional stress - Young adults undergoing persistent or intermittent stress like anticipating military conflict) experienced substantial decreases in their overall and plasma magnesium concentrations over three months.”

“2003 According to Luc van Loon, 0.8 g/kg/day represents the minimum protein requirement to stay in nitrogen balance for a diet that is provided for 1–2 weeks, but this is not the protein requirement for optimal health, nor does it account for individual variations in protein needs due to age, physical activity levels, and health status.”

“1 2 3 00:31:57 - How skill-based exercise, such as yoga, Tai chi, boxing, tango or skateboarding may play a special role in ameliorating some of the effects of the disease by driving circuit-specific effects, by creating top-down cognitive challenge for skills involved in a patient's movement through space.”

“The study involved 112 women between the ages of 39 and 59 years who were assigned to take a placebo (500 milligrams of cellulose) or a commercial product (containing 300 milligrams of hydrolyzed type II collagen, 100 milligrams of chondroitin sulfate, and 50 milligrams of hyaluronic acid) twice a day for 12 weeks.”

“Researchers evaluated the effects of these changes in a study involving 37 men and women who practiced voluntary long-term caloric restriction (approximately 30 percent of habitual intake) for 3 to 15 years, compared to sedentary and fit people eating a traditional Western diet.”

“Neurogenesis Whereas the early view of the mammalian central nervous system presumed that it was a static complex incapable of change, a growing body of evidence suggests that it retains its capacity for synaptic pruning – the process that eliminates extra neurons and synaptic connections and establishes new neural circuits to increase the efficiency of neuronal transmissions – throughout life.”