Search results for metabolism

“Aging in tumor tissue is markedly accelerated, however – an indicator of the perturbed metabolic and growth processes observed in cancer. In this clip, Dr. Steve Horvath discusses correlations between epigenetic aging and age-related chronic diseases.”

“This elephant in the room can’t be ignored when answering the question about diet and heart disease. Refined sugar intake matters, too A diet high in saturated fat sets us up for a litany of ills related to fat metabolism.”

“They also measured blood markers related to metabolism and inflammation, and analyzed whether genetic differences in omega-3 metabolism changed the results. Over the study period, 5,671 participants developed severe NAFLD based on hospital or mortality records.”

“Dr. Verdin's laboratory focuses on the role of epigenetic regulators in the aging process, the role of metabolism and diet in aging and on the chronic diseases of aging, including Alzheimer’s, proteins that play a central role in linking caloric restriction to increased healthspan, and more recently a topic near and dear to many of you, ketogenesis.”

“Assessments included measures of mitochondrial fuel oxidation, oxidative stress, inflammation, glucose metabolism, body composition, and strength tests, among others. The old adults took a GlyNAC supplement (dose varied according to the participants' bodyweight) every day for 24 weeks; the young adults did not take a GlyNAC supplement.”

“In this clip, Dr. Elissa Epel explains how these aging syndromes – as well as other factors that affect telomere length – can also be passed to offspring via epigenetic mechanisms.”

“A critical element in the mechanisms that regulate autophagy is the cell’s ability to sense changes in cellular levels of acetyl CoA, an end product of nutrient metabolism. When mice or humans are deprived of nutrients, protein deacetylation – which often coincides with autophagy – begins to occur on the organism-wide level.”

“Apolipoprotein E (APOE), a lipoprotein produced in the liver and the brain, plays key roles in fat metabolism. Approximately 25 percent of people in the United States – roughly 75 million people – carry a genetic variant of this lipoprotein called APOE4, which is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.”

“Apolipoprotein E (APOE), a lipoprotein produced in the liver and the brain, plays a key role in fat metabolism. Approximately 25 percent of people living in the United States carry a genetic variant of this lipoprotein called APOE4, which is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.”

“However, this result only occurred in cancer cells with an acidic pH compared to a neutral pH. Mice that received the fish oil supplementation lost harmful white adipose tissue but gained metabolically beneficial brown adipose tissue, improving whole-body metabolism.”