Can limiting protein intake (or other selective nutrient depletion) induce autophagy?
A critical element in the mechanisms that regulate autophagy is the cell’s ability to sense changes in cellular levels of acetyl CoA, an end product of nutrient metabolism. When mice or humans are deprived of nutrients, protein deacetylation – which often coincides with autophagy – begins to occur on the organism-wide level. Whether removal of single nutrients induces the same changes is not known. In this clip, Dr. Guido Kroemer describes the interplay between protein deacetylation and autophagy.
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