Search results for mitochondria

“NF-kB influences several aspects of the body’s stress response via its participation in signaling pathways that drive pro-inflammatory processes, ultimately regulating DNA transcription, cytokine production, cell survival, and immune function.”

“FTA: > An association between biological changes on the cellular level and both childhood adversity and psychiatric disorders has been identified by researchers. These changes in the form of telomere shortening and alterations of mitochondrial DNA (mtDNA), are important in the aging process.”

“Previously, the FDA warned that NSAIDs increase heart attack and stroke risk even with short-term use. NSAIDs disrupt mitochondrial function in heart cells and also endothelial nitric oxide production in blood vessels & may partly explain why chronic use increases the risk of heart attack.”

“First identified in semen, spermidine demonstrates anti-aging properties in animal studies, likely due to its capacity to induce autophagy – the process by which the body clears dead and damaged cells.”

“Moderate intensity exercise releases a lipid-controlling hormone (called lipokine) that causes skeletal muscle to take up fatty acids (in both mice and humans). The release of the lipokine also correlated with an increased capacity for mitochondrial energy production in humans and improved VO2max. It also seems to decrease circulating triglycerides.”

“Impaired brain energy metabolism, characterized by mitochondrial dysfunction and poor glucose utilization, are common features of Alzheimer’s disease. Evidence suggests that creatine, a nutritional supplement that participates in cellular metabolism, enhances cognitive function in older adults.”

“PQQ is present in a variety of foods such as parsley, green tea, and fermented soybeans. PQQ is also abundant in human breast milk. The estimated daily intake of PQQ from typical foods and beverages are 0.01–0.4 mg/day. PQQ is an anti-oxidant and promotes mitochondrial biogenesis. Reduced PQQ exhibits a high anti-oxidant capacity that is 7.5-fold greater than that of ascorbic acid.”

“Maternal obesity accelerated markers of aging in offspring including impaired mitochondrial function, early signs of prediabetes, fatty liver, and oxidative stress. Exercise by the offspring improved many of the poor outcomes (animal study).”

“Here’s an interesting report that didn't make it into this issue of the Digest. Fructose metabolism is a survival mechanism that drives nutritional intake, reduces resting metabolism, promotes fat and glycogen storage, and induces insulin resistance to preserve the brain's glucose supply.”

“Fathers passed on exercise-related traits to their offspring including improved cognition, increased neurogenesis, and enhanced mitochondrial activity. These changes were passed down because of specific gene changes in the fathers’ sperm (animal study).”