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“Dr. Roland Griffiths is a clinical pharmacologist at Johns Hopkins and one of the world's foremost researchers on the psychedelic compound psilocybin. Learn more about Dr. Roland R. Griffiths Johns Hopkins Profile - Roland R. Griffiths. List of Publications.”

“As a result, sauna use is associated with lower risk of cardiovascular and neurodegenerative diseases. The mechanisms that drive these effects are likely due to increased heat shock proteins and metabolic and hormonal changes that accompany exercise and sauna use.”

In this clip, Drs. Levine and Patrick discuss lifestyle factors that accelerate epigenetic aging including smoking cigarettes or having a low omega-3 index.

“Online resources that combine healthful practices and feedback may be beneficial for some people with depression but tapping into the benefits of less modern practices may be beneficial, too. Ancient practices, such as heat exposure, long-distance running, and fasting may promote mental well-being.”

“Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects.”

Many of the anabolic effects of growth hormone are thought to be mediated by insulin-like growth factor-1, or IGF-1 (https://www.ncbi.nlm.nih.gov/pubmed/18500379), which is synthesized primarily in the liver but also in skeletal muscle in response to growth hormone.

Dan Pardi: Ph.D. candidate studying sleep neurobiology at Stanford and University of Leiden, co-founder of Dan’s Plan online wellness company.

“Exercise produces similar results by releasing anti-inflammatory cytokines that may contribute to an anti-depressant outcome. In this clip, Dr. Charles Raison describes how whole-body hyperthermia has the potential for real-world clinical efficacy as a tool in the fight against major depression.”

Dr. Rhonda Patrick explores melatonin's antioxidant properties, curcumin supplementation, antinutrients, and SARMs in her latest Q&A.

Tim Ferriss discusses ketosis, the gut microbiome, and monitoring biomarkers to promote performance.