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“Sugar substitutes are food products or additives that provide the sweet taste of sugar, without the calories. Evidence suggests that sugar substitutes have surprising effects on human metabolism and these effects vary person-to-person, based on the overall makeup of an individual's gut microbiome.”

“In this Aliquot, Dr. Andrew Huberman and I explore the complexities of digital engagement, share strategies for managing technology use, and discuss the importance of establishing boundaries that promote mental health and personal growth.”

“In Aliquots #131 and #133, leading researcher Dr. Darren Candow and I examined creatine's benefits for muscle quality, physical function, skeletal health, and brain resilience, especially in older adults.”

Tim Ferriss discusses ketosis, the gut microbiome, and monitoring biomarkers to promote performance.

“When Dr. Bill Harris began researching omega-3 in the early 1980s, he was looking for an impact on cholesterol with what would be considered a high dose by today's standards: around 25 effective grams per day of omega-3 from salmon.”

“A second randomized trial found that a single vitamin D3 dose taken with food increased vitamin D status, with a larger rise when the meal contained at least 15 grams of fat. These findings support taking vitamin D with a meal that contains some fat.”

“Dr. Patrick treats magnesium L-threonate separately. Early human findings are limited by small studies, industry funding, and products that sometimes include coingredients, making it difficult to attribute effects to L-threonate alone.”

“Having sufficient muscle mass markedly reduces a person's risk of dying prematurely, and actively challenging those muscles, through regular physical activity and exercise, may extend a person's life several years.”

“A meta-analysis of 49 studies involving 1,863 adults found that protein supplementation during prolonged resistance training produced additional gains in one-repetition maximum strength, fat-free mass, and muscle size compared with training alone.”

“Researchers believe incorporating these fatty acids into mitochondrial membranes might alter ADP handling and oxygen utilization, potentially affecting muscle protein synthesis and energy production.”