A new experimental drug was able to rejuvenate stamina, organ function, and regrow hair in old mice by selectively clearing away senescent cells.
“Senescent cells form after cells have accumulated too much damage. They are cells that are no longer functioning but are not dead either. They secrete many proteins including proinflammatory molecules which cause damage to nearby cells and accelerate the aging process.”
Episode
The Optimal Creatine Protocol for Strength, Brain, and Longevity | Darren Candow, PhD
“"Creatine causes hair loss or baldness" A single study linking creatine supplementation to increased DHT (dihydrotestosterone) has not been replicated or associated with actual hair loss. Current evidence strongly suggests creatine does not cause baldness.”
Pregnant females are exposed to a variety of toxic chemicals via common household products.
“Levels were highest in Black and Hispanic females and those with greater exposure to tobacco. In addition, nearly all the samples contained nitrogen-containing compounds called aromatic amines, which are commonly used in products containing dyes and pigments, such as hair dyes and cosmetics.”
Girls on average enter puberty between one-and-a-half and three months earlier, if mother took acetaminophen for >= 12 weeks during pregnancy
“Starting at the age of 11 years and continuing every six months until they reached sexual maturity, the children provided information about their achievement of specific puberty-related events, such as underarm hair growth, menarche (the first period), first ejaculation, and others.”
Living in areas with high environmental pesticide exposure may increase cancer risk.
“Cancer rates ranged from 14% above expected up to about 9 times higher, with an overall increase of about 2.5 times. Measurements from hair samples in 50 residents matched the exposure map, suggesting the model reflects real-world exposure patterns.”
Zinc deficiency promotes inflammation and weakens immunity, especially in older adults.
“Severe zinc deficiency results in growth retardation, hair loss, skin sores, and depressed immunity and is uncommon in developed nations. However, marginal deficiency, which is asymptomatic and dangerous over long periods of time, is likely very common.”
A 6-hour eating window led to weight loss and improved hormonal markers in overweight or obese women with polycystic ovary syndrome.
“Common PCOS-related symptoms and risk factors, including irregular cycles, excess hair growth, acne, oily skin, elevated blood pressure, and abnormal blood lipid levels, did not differ clearly between groups.”
Episode
Axel Montagne, Ph.D. on Blood-Brain Barrier Dysfunction in Alzheimer’s Disease and Dementia
“- Axel Montagne, Ph.D. While we await potential breakthroughs in targeting elements of the neurovascular unit in the blood-brain barrier directly with stem cell therapeutics, gene therapies, and other cutting-edge techniques, there are things we can do now to better support vascular health and thereby help maintain the integrity of the blood-brain barrier.”
Episode
How to Train According to the Experts
“It is considered safe with no evidence for hair loss or kidney damage in healthy adults. A dose of 3-5 grams per day is recommended. Omega-3s may play a role in preserving muscle mass, especially in older adults due to their anti-catabolic effects.”
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