Search results for fasting

“Interventions such as fasting or the ketogenic diet alone are not sufficient for cancer treatment, because some cancer cells can adapt. However, the triad of the ketogenic diet, a fasting-mimicking diet, and standard of care treatments (such as chemotherapy or immunotherapy) holds promise for particularly aggressive phenotypes, such as gliomas.”

“Fasting has been shown to have powerful effects in animal models, although translating these results for human models is crucial. Initially, researchers had difficulty recruiting patients to participate in clinical trials involving prolonged fasting as both doctors and patients expressed concerns about safety and tolerability.”

“Human muscles are a mix of both, with elite athletes having more of one type depending on their specialization. As people age, there's a noticeable loss of fast-twitch fibers, emphasizing the importance of strength training for older adults to counteract risks like falls and frailty.”

“Artificially reversing this process in the laboratory – providing nutrients to sick animals – has proven fatal. In this clip, Dr. Guido Kroemer describes how fasting associated with sickness behavior is critical to surviving infection.”

“Interestingly, calorie restriction boosts the production of sirtuin enzymes. Later discoveries revealed that the benefits of calorie restriction (and the subsequent increase in sirtuins) could also be obtained via intermittent fasting.”

“While there is much to understand about the mechanistic details of the fasting-mimicking diet, the clinical benefits are clear. In this clip, Dr. Valter Longo discusses how fasting can play a role in the activation and renewal of stem cells by altering the metabolic profile.”

“The fasting-mimicking diet decreases visceral fat and researchers suspect that the fat-burning mode continues for some time after fasting has stopped. Upon refeeding, muscle mass is rebuilt and contributes to an overall increase in percentage of lean body mass.”

“Over time, exercise enhances the parasympathetic nerves that innervate the heart, slowing heart rate, and improving health. In this clip, Dr. Mark Mattson explains the importance of stressing the cardiovascular system with behaviors such as exercise and fasting to maximize health.”

“Dr. Patrick explains some of the early evidence that suggests the value prolonged fasting (48+ hours) may have from the standpoint of tissue rejuvenation and healthspan maintenance, as well as relevance for other more specific conditions.”

“Differential stress resistance is a property that is characteristic of prolonged fasting. During a prolonged fast normal cells develop a tendency to become more resilient to stress, whereas cancer cells are unable to do this as a consequence of oncogenic signaling.”