The link between sirtuins, calorie restriction, fasting, and the insulin pathway | David Sinclair

Parent Episode: Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

Early discoveries in aging research revealed that sirtuins, a class of enzymes that control gene expression, modulate lifespan by mimicking the effects of calorie restriction – the chronic reduction of energy intake. Interestingly, calorie restriction boosts the production of sirtuin enzymes. Later discoveries revealed that the benefits of calorie restriction (and the subsequent increase in sirtuins) could also be obtained via intermittent fasting. The mechanisms that link various forms of dietary restriction and sirtuin production are inextricably tied to lower levels of insulin and IGF-1. In this clip, Dr. David Sinclair describes how sirtuins, caloric restriction, fasting, and the insulin-IGF-1 pathway converge to modulate aging and lifespan.

Member support keeps us strong.

If you enjoy the fruits of foundmyfitness, you can participate in helping us to keep improving it. Creating a pay-what-you-can subscription does just that! Plus, we throw in occasional member perks and, more importantly, churn out the best possible content without concerning ourselves with the wishes of any dark overlords.

Our website is 100% supported by people like you through this pay-what-you-can mechanism.

Monthly Support

  • Fundamentals

    $15 / month
  • Loyal Fan

    $25 / month
  • Super Fan

    $50 / month
  • Power Supporter

    $125 / month
  • Heroic Supporter

    $250 / month

One-time Support

You can also become a one-time supporter with a single donation in any amount.