Gut bacteria metabolized dietary tryptophan into a compound called I3S that gets into brain & causes astrocytes to switch to anti-inflammatory mode.
“These experiments were done in a mouse model of multiple sclerosis (MS) but blood samples from MS patients were found to have decreased levels of these tryptophan-derived molecules that lower brain inflammation.”
Damage to gut barrier function mediated by inflammation found in mouse model of early presymptomatic stage of multiple sclerosis
“The condition is called 'leaky gut syndrome'. Our studies indicate a leaky gut and increased inflammation in the intestinal mucous membrane and related lymphoid tissue before clinical symptoms of MS are discernible.”
Vitamin C
“Common neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. Several factors drive neurodegeneration, but oxidative stress likely mediates and enhances the processes involved.”
Bacteria in the gut shown to produce certain inflammatory compounds in the brain through communication with brain cells.
“Bacteria in the gut shown to produce certain inflammatory compounds in the brain through communication with a type of immune cell in the brain called microglia (in mice). These brain inflammatory compounds were elevated in tissue samples from patients with multiple sclerosis.”
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Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More
“In older age, vitamin C's antioxidant capacity might be beneficial in decreasing the risk of neurodegenerative conditions like Alzheimer's disease, Parkinson's disease, Huntington’s disease, and multiple sclerosis by reducing oxidative damage – a key driver of neurodegenerative disease.”
Fasting-like diet kills autoimmune cells & replaced them with healthy cells & improved symptoms in MS patients.
“This fasting-like diet also promotes regeneration of the myelin in mice with multiple sclerosis. In human patients with multiple sclerosis, the fasting-like diet led to improvements in symptoms if followed by a Mediterranean diet or a ketogenic diet.”
Skin cells re-programmed into brain stem cells reduced inflammation and repaired some damage caused by multiple sclerosis (mouse study).
“The goal here is to be able to make brain stem cells by taking a person's skin cells and reprogramming them back into neural stem cells. They would be much less likely to induce an immune response since they would be the patient's own cells.”
A mother’s gut microbiome linked to immune activation and with increased susceptibility of her offspring to developing autism spectrum disorder.
“This animal study found that maternal microbiome was specifically linked to immune activation through the production of a proinflammatory cytokine called IL-17a, which has also been linked to rheumatoid arthritis, multiple sclerosis, and psoriasis.”
Results 41–50 of 91