Gut bacteria use flavonoids (fruits, teas) to control the immune response and protect against the influenza virus.
“Gut bacteria use flavonoids (found in fruits, teas, etc.) to control the immune response and protect against severe damage from the influenza virus (in mice). The specific human-associated gut microbe that protected against the influenza virus is called Clostridium orbiscindens.”
Microbiome signatures distinguish adults with depression from healthy counterparts.
“Authors of a new report aimed to identify which specific microbial and metabolic biomarkers are altered in patients with depression. Changes to the microbes that live in the gut or the metabolites that these microbes consume and produce may be responsible for the development and severity of depression.”
Prebiotics may help restore circadian rhythms.
“The rats on the prebiotic diet also had greater abundance of several health-promoting microbes, including Ruminiclostridium 5, compared to those on the standard diet. Previous research indicates that Ruminiclostridium 5 is associated with improved sleep.”
Supplemental vitamin K2 improves diabetes markers and glycemic control.
“Similarly, the mice demonstrated improved glucose tolerance after receiving the gut microbe transplants. Lastly, the researchers found that certain metabolites that play roles in glucose metabolism, including bile acids and short-chain fatty acids, increased in the feces of both groups.”
Pre-existing antibody patterns helped identify people with weaker vaccine responses.
“Pre-existing antibodies to common microbes distinguished strong from weak COVID-19 vaccine responders across several clinical groups. The AI model applied across all groups captured part of that signal, identifying about six in ten weak responders while correctly classifying eight in ten stronger responders.”
Single course oral fecal microbiota transplant in adolescents with obesity linked to lower body fat and metabolic risk four years later.
“Researchers tested whether taking capsules containing gut microbes from healthy donors during adolescence could leave durable clinical and microbiome changes years later. Researchers followed up on a previous trial where adolescents received either gut microbiota from healthy lean adults or a placebo.”
Episode
Joe Rogan Experience #901 - Dr. Rhonda Patrick
“01:54:00 - Pterostilbine increases gut microbes that convert ellagitannins to urolithin A, which induces mitophagy. Press release. 01:57:05 - Rhonda explains the process of mitophagy – the clearing away of damaged mitochondria.”
Pneumonia-causing bacteria release large amounts of hydrogen peroxide to inactivate the inflammasome and evade the immune response
“Our studies demonstrate that hydrogen peroxide is an inhibitor of an important component of the inflammatory machinery suggesting that the mechanism we have uncovered is a common strategy employed by many microbes to thrive within us," says Saskia Erttmann, first author in the study and former member of Nelson Gekara's research group.”
Our gut microbiomes aren’t getting enough fibre, but supplements can help
“Participants whose diets were low in dietary fiber experienced marked increases in butyrate production in their guts, likely due to increases in butyrate-producing microbes. However, participants whose diets were in high in dietary fiber experienced little change in the makeup of their gut microbes.”
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