Search results for epigenetics

“A low protein diet (9% of total calories) caused changes in testicular epigenetics and males had offspring that were overweight with symptoms of type 2 diabetes and reduced activation of genes which regulate fat metabolism (mouse study).”

“From the article: > In mice, the scientists showed that learning ability was passed onto the next generation by epigenetic inheritance. When Fischer and co-workers exposed mice to a stimulating environment in which they had plenty of exercise, their offspring also benefited: compared to the mice of a control group, they achieved better results in tests that evaluate learning ability.”

“The antiaging properties of metformin appear to extend beyond glucose and insulin signaling pathways, however, to address the primary hallmarks of disease and aging, including inflammation, altered cell signaling, mitochondrial dysfunction, epigenetic modification, telomere loss, genomic instability, and cellular senescence.”

“Still, if these findings are confirmed in broader studies and intervention trials, aging tests such as DunedinPACE could become useful tools for tracking how lifestyle and other preventive strategies relate to long-term aging and disease risk. In episode #62, Dr. Steve Horvath discusses epigenetic aging clocks and their use in predicting biological aging and healthspan.”

“Epigenetic effects of alcohol and tips for future parents "Expecting parents or those trying to conceive should think about cutting out their alcohol consumption at least three months before they start trying. Furthermore, there is no safe level of alcohol consumption during pregnancy."”

“Epigenetic clocks may be a potent way of gauging the successfulness of anti-aging interventions that is resistant to accidental artifact in the lab. In vivo, the epigenetic changes that occur over time as a person ages, Dr. Horvath says, are more stable than gene expression, proteomics, and metabolomics measurements.”

“But could aging become reversible in the future? Technologies like interrupted cellular reprogramming, in combination with future advances in the field of epigenetics, offer the promise that scientists may eventually be able to develop the means to reverse aging.”

“Scientists are exploring a wide range of cutting-edge therapies aimed at understanding and manipulating the complex processes underlying these hallmarks, including epigenetic aging clocks and pluripotent stem cells.”

“In part I of this two-part series on the future of aging research, we discussed the hallmarks of aging and the cutting-edge therapies aimed at understanding and manipulating the complex processes underlying these hallmarks, including epigenetic aging clocks and pluripotent stem cells.”

“Chromatin is wrapped around histone proteins that open or close the chromatin, based on whether the histone has a chemical tag called an acetyl group attached or not. As DNA accumulates epigenetic changes over the lifespan, histones become resistant to acetylation, chromatin is harder to open, and gene expression slows.”