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“Increased activity of β-catenin is known to be a major factor in the development of many cancers and can make normal cells immortal, a key step in early stages of cancer progression.”

“Foxo3 is a master regulator of hundreds of genes that are involved in stress resistance, autophagy, and stem cell production. Humans that have a certain variation that make the foxo3 gene active more often have a 2.7-fold increased likelihood of living to be a centenarian.”

“Moreover, inflammation can be clinically monitored by well-known biomarkers for systemic inflammation, making it amenable to potentially tracking therapeutic success: the risk of major depression has been shown to increase by 44% for each standard deviation increase in log c-reactive protein.”

“This is because it is complexed to a fiber matrix (which alters gut absorption and metabolism). Fruit also contains a plethora of unique prebiotics that are beneficial to gut health and immune health as well as a multitude of hormetic plant compounds which are also very beneficial for health.”

“Dr. Michael Grandner describes this as the "mind after midnight"— being awake past our normal bedtime biases us toward reward-seeking, negative affect, and weaker executive control, helping explain not only late-night eating (a preference for energy-dense, high-fat, and high-sugar foods) but other impulsive behaviors that occur at this time.”

“A single-nucleotide polymorphism (SNP) in the gene that encodes BDNF causes a substitution of the amino acid valine (Val) by methionine (Met) in a specific region of the DNA where the gene is located.”

“Study. 01:43:00 - High animal protein intake was only positively associated with cardiovascular mortality among individuals with at least one unhealthy lifestyle risk factor, such as obesity or sedentary lifestyle. Study.”

“The participants took memory tests and mental health surveys before and after engaging in their randomly assigned respective activities: no exercise; four weeks of exercise with exercise and a test on the last day; four weeks of exercise, without exercise on the final test day; or a single bout of exercise on the last test day.”

“The good news is that extending sleep by ~1 hour per night has been shown to improve insulin sensitivity, normalize levels of appetite-regulating hormones, reduce cravings for sweet and salty foods, decrease sugar consumption, lower caloric intake, and aid in weight loss.”