Related Episodes for Human dose extrapolation

“To look for functional mitochondrial effects, Dr. Attia uses controlled Zone 2 work while sampling lactate, with output near 2 mmol/L. He says statins have not produced the clear lactate-performance changes he sees with metformin.”

“A systematic review and meta-analysis of 44 randomized trials found that berberine improved several surrogate measures, including inflammatory biomarkers, stroke-related neurological deficit scores, and carotid intima-media thickness.”

“A separate study of 17 recently abstinent heavy cannabis users found poorer sleep efficiency, longer sleep onset, and less slow-wave sleep than in 14 drug-free controls, consistent with withdrawal-related sleep disruption.”