FoundMyFitness library
Ranked by shared topics.
“If you focus on eating multiple protein-containing meals each day and are thoughtful about your sources, it's likely you'll meet daily protein needs and thrive, whether your goal is gaining more muscle or just staying strong into your later years.”
“While aerobic exercise is often viewed preferentially through the lens of cardiovascular health, the diverse cascade of biological effects from exercise as a whole — and aerobic exercise, in particular — culminate to make it one of the most formidable and immediately practical real-world interventions for human aging and the brain.”
“Caloric restriction, a potent inducer of autophagy, extends lifespan in many organisms but also reduces the risk of many age-related chronic diseases, such as diabetes, cardiovascular disease, cancer, and brain atrophy – likely attributable to the beneficial effects of autophagy.”
“Assessments of episodic memory based on a battery of cognitive tests demonstrated that the rate of cognitive decline experienced by healthy, older people who had amyloid-beta protein accumulation in their brain and who were APOE4 and BDNF Met carriers was roughly three times the rate of decline among those carrying only the BDNF Val allele (the more common form of the gene that retains valine).”
“A mouse study demonstrated that oral berberine (50 or 100 mg/kg/bw per day) reversed the depression-inducing effects of corticosterone injection by upregulating hippocampal synthesis of brain-derived neurotrophic factor – a type of protein that acts on neurons in the central and peripheral nervous systems and may be important for the antidepressant response.”
“However, two small, randomized, double-blind, placebo-controlled experiments in which participants received BHB supplements (as ketone salt or ketone monoester) found that various markers of NLRP3 inflammasome activation, including caspase-1 and interleukin 1-beta, increased, suggesting that the ketones may have unintended proinflammatory effects.”
Biological aging clocks use DNA methylation patterns and other biomarkers to estimate different dimensions of biological aging, including how old the body appears at the molecular level, how quickly aging-related changes are accumulating, and whether lifestyle or medical interventions may be changing the trajectory of aging.
“The most useful next studies would directly test banana-blueberry combinations, compare standardized berry preparations, identify which populations benefit, and follow clinical outcomes rather than relying only on surrogate markers.”
“However, findings from a rodent study indicate that even low levels of nicotine exposure during pregnancy or early in life can increase the risk of sudden infant death syndrome, or SIDS, by inhibiting the neonate's ability to autoresuscitate – the capacity to recover from prolonged periods of apnea, widely considered a causal factor in SIDS.”
“Microbial production of short-chain fatty acids, including acetate and propionate, occurs in the colon during the fermentation of indigestible fibers found in plant foods such as legumes, fruits, nuts, cereals, and whole grains.”