Related Episodes for Can someone with an APOE4 genotype follow a ketogenic diet? | Dominic D'Agostino

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“While the alcohol concentration in breast milk is low, infants cannot metabolize it very well and can cause altered sleep habits, decreased appetite, weight gain, low blood sugars, and impaired motor development.”

“In this clip from Dr. Rhonda Patrick's conversation with Derek from More Plates More Dates, she describes the large glucose changes she observed during fragmented postpartum sleep and explains why she uses brief, intense exercise after poor sleep during travel.”

“Time-restricted eating can help some people reduce eating opportunities, although a 12-month trial found no additional weight or body-fat benefit when an eight-hour eating window was added to calorie restriction. Sleep also affects appetite and fat distribution.”

“In a randomized crossover study of 18 young men with overweight or obesity, ten three-minute walking or squat breaks spaced every 45 minutes across 8.5 hours lowered post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”

“In more than 25,000 adults who reported no leisure-time exercise, a median of three one- or two-minute bouts per day was associated with 38 to 40 percent lower all-cause and cancer mortality and 48 to 49 percent lower cardiovascular mortality compared with no VILPA.”

“In this clip from Dr. Rhonda Patrick's appearance on The Diary of a CEO, she explains that a shorter eating window can make calorie reduction easier, while a longer overnight fast shifts fuel use toward fatty acids and ketones.”

“In eight young men, seven days of 1,000 milligrams of NR per day changed selected muscle NAD metabolites but did not alter substrate use, mitochondrial respiration, or signaling involved in adaptation to one hour of endurance exercise.”

“In the prospective Framingham Offspring Study, people in the highest red-blood-cell DHA group had approximately 49 percent lower risk of developing Alzheimer's disease than those in the lowest group.”

“Heat stress activates molecular chaperones that help fold damaged proteins and maintain proteostasis, while heat therapy may also influence vascular and metabolic pathways relevant to cognitive aging. A prospective Finnish study followed 2,315 middle-aged men for a median of 20.7 years.”