Autophagy and cancer: a crucial role in immunosurveillance and chemotherapeutic treatment
Autophagy triggers cellular immunosurveillance mechanisms by facilitating the release of ATP from dying cells. ATP is perceived as a threat and attracts the attention of the immune system's myeloid cells via a special class of receptor known as purinergic receptors. Activation of this important system of immunosurveillance is a predictor of the long-term efficacy of chemotherapy and may help to explain the complex relationship of autophagy with cancer, wherein the initial suppression of autophagy may help prevent attracting undue attention from the immune system, but may later facilitate ongoing transformation. In this clip, Dr. Guido Kroemer explains the complex relationship that exists between cancer cells, the immune system, and autophagy.
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