Autophagy and cancer: a crucial role in immunosurveillance and chemotherapeutic treatment

Parent Episode: Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation

Autophagy triggers cellular immunosurveillance mechanisms by facilitating the release of ATP from dying cells. ATP is perceived as a threat and attracts the attention of the immune system's myeloid cells via a special class of receptor known as purinergic receptors. Activation of this important system of immunosurveillance is a predictor of the long-term efficacy of chemotherapy and may help to explain the complex relationship of autophagy with cancer, wherein the initial suppression of autophagy may help prevent attracting undue attention from the immune system, but may later facilitate ongoing transformation. In this clip, Dr. Guido Kroemer explains the complex relationship that exists between cancer cells, the immune system, and autophagy.

Member support keeps us strong.

If you enjoy the fruits of foundmyfitness, you can participate in helping us to keep improving it. Creating a pay-what-you-can subscription does just that! Plus, we throw in occasional member perks and, more importantly, churn out the best possible content without concerning ourselves with the wishes of any dark overlords.

Our website is 100% supported by people like you through this pay-what-you-can mechanism.

Monthly Support

  • Fundamentals

    $15 / month
  • Loyal Fan

    $25 / month
  • Super Fan

    $50 / month
  • Power Supporter

    $125 / month
  • Heroic Supporter

    $250 / month

One-time Support

You can also become a one-time supporter with a single donation in any amount.