Periodic fasting has the same longevity benefit as caloric restriction | Guido Kroemer

Parent Episode: Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation

Calorie restriction, a promising strategy to extend lifespan, causes significant weight loss in mice. However, this dietary regimen is very difficult to adhere to. Interestingly, mice that are fed on an intermittent fasting schedule adjust to their restricted regimen and, in the end, tend to weigh as much as mice fed on a normal schedule, but they exhibit many of the physiological responses – including induction of autophagy – as calorie-restricted mice. In this clip, Dr. Guido Kroemer describes how intermittent fasting recapitulates the life-extension benefits of caloric restriction without some of the drawbacks.

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