Increasing general autophagy as a treatment for neurodegenerative diseases like Parkinson's disease
Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are characterized by protein aggregation and mitochondrial dysfunction, due in part to mitophagy failure. An emerging strategy in the prevention and (possibly) treatment of neurodegenerative diseases is starving cells as a means to induce general autophagy to help rid the cell of protein aggregates. In this clip, Dr. Guido Kroemer describes how mitophagy contributes to the pathophysiology of neurodegenerative disease and how autophagy might mitigate these processes.
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